教授
常凌乾
教授,博士生导师
 

常凌乾

博士 教授 青年千人 博士生导师 北京航空航天大学 生物与医学工程学院

电子邮件:changlingqian1986@buaa.edu.cn

主要教育、科研简历

2004.08 – 2008.07: 大连理工大学 电子工程专业 学士

2008.09 – 2011.07: 中科院电子学研究所  传感技术国家重点实验室  硕士

2011.09 – 2016.07: 美国Ohio State University 生物医学工程系 博士

2016.09 – 2017.07: 美国Northwestern University 机械工程系 CCNE中心 博士后

2017.09 – 2018.12: 美国University of North Texas 生物医学工程系 助理教授 (Tenure Track)

2018.12 – 至今:   北京航空航天大学、生物与医学工程学院 教授

 

研究方向:

生物微机电系统、生物微纳米芯片、单细胞分析、生物传感器

 

在研科研项目:

  1. 千人计划青年项目,2019-
  2. 生医高精尖中心——单细胞分析纳米技术研究所 启动经费,2019-

 

Ø  学术兼职

2019, 第二届细胞生物信息学研讨会,会议主席

2019,Microsystem and Nanoengineering Summit 2019, Poster Session, 评委

2019, Nanotechnology and Precision Engineering (中国微纳米技术学会会刊), 编委

2019,中国微纳米技术学会,高级会员

2019,中国生物医学工程学会纳米医学与工程分会,青年委员

2018, BioMedical Engineering Online, (SCI 期刊),副主编

2018, Electroporation Protocol, Springer Nature, 主编

2018,Second Texas Symposium on Computing with Emerging Technologies,分会主席

2014 – 现在,Computers in Biology and Medicine (SCI 期刊),编委

2015 – 现在,European Journal of Biomedical Research,副主编

2017 - 现在,Biomedical Engineering Society (BMES), 会员

2013 – 2014,International Society for Optical Engineering (SPIE), 会员

2013 – 2015,American Society of Mechanical Engineers (ASME), 会员

获奖与荣誉:

l  2018,杰出青年科学家(提名)奖,MINE 2018

l  2018,Research Seed Grant (RSG) Award,美国北德克萨斯大学

2017,中组部千人计划青年项目,中国

l  2016, 三束纳米制造会议(EIPBN)Travel Award,美国,匹兹堡

2015 Presidential Fellowship(博士最高奖), 美国俄亥俄州立大学

l  2015, 三束纳米制造会议(EIPBN)Travel Award,美国,圣地亚哥

2014 NSEC Fellowship, National Science Foundation (NSF), 美国纳米科学工程中心

2013 NSEC Fellowship, National Science Foundation (NSF),美国纳米科学工程中心

2012 NSEC Fellowship, National Science Foundation (NSF),美国纳米科学工程中心

2011 University Fellowship, 美国俄亥俄州立大学

l  2008, “优秀毕业生”,大连理工大学

l  2004-2006,年度综合奖学金,大连理工大学,电子工程系

 

近五年代表性论文:

Ø  著书章节(# 共同第一作者;* 通讯作者)

1.       L. Chang*, C. Chiang, Y. Jiao, L. Teng, Non-viral transfection methods for efficient gene delivery: Micro-/nano-technology for electroporation. “The World Scientific Encyclopedia of Nanomedicine and Bioengineering I: Volume 3: Nanotechnology in Gene Delivery”. World Scientific Publisher, Oct 2016, 175-218. ISBN: 978-981-4667-65-4

2.       L. Chang*, S. Black, C. Chitrakar, M. Nouri, 3D Nanochannel Array for High-Throughput Cell Manipulation and Electroporation. “Methods in Molecular Biology: Electroporation Protocols”. Springer Nature, Oct 2019, ISBN: 978-1-4939-9740-4.

3.       L. Chang*, C. Chitrakar, M. Nouri, 3D Nanochannel electroporation for macromolecular nucleotides delivery. “Methods in Molecular Biology: Electroporation Protocols”. Springer Nature, Oct 2019, ISBN: 978-1-4939-9740-4.

 

 

Ø  期刊论文(# 共同第一作者;* 通讯作者)

 


  • 代表性论文

1.       Z. Dong, Y. Jiao, Y. Hao, P. Wang, J. Shi, W. An, C. Chichtrakar, S. Black, L.J. Lee, M. Li, Y. Fan, L. Chang*, On-Chip Multiplexed Single-cell Pattern and Controllable Intracellular Delivery. Microsystem and Nanoengineering, 2019. DOI: 10.1138/s41378-019-0112-z.  (IF: 6.0) (一区Top)

2.       L. Chang, Y. Wang, F. Ershad, R. Yang, C. Yu, Y. Fan, Wearable Devices for Single Cell Sensing and Transfection. Trends in Biotechnology, 2019, DOI:   10.1016/j.tibtech.2019.04.001. (IF: 13.7) (一区Top)

3.       Y. Zhu, J. Shen, L. Yin, X. Wei, F. Chen, M. Zhong, Z. Gu, Y. Xie, W. Jin, Z. Liu, C. Chitrakar, L. Chang, Directly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene “click” reaction: Enhanced mechanical property and

excellent biocompatibility. Chemical Engineering Journal, 2019, 366, 112-122.

(IF: 8.4) (一区Top)

4.       F. Chen, Y. Zhu, W. Li, J. Yang, P. Fan, M. Zhong, L. Chang*, Tairong Kuang*, Light-triggered pH/Thermal Multi-Sensitive Polyelectrolyte/ITO Glass Hybrid Electrode. Applied Surface Science. 2019, 464, 273-279. (IF: 5.2)

5.       W. Bai, T. Kuang, C. Chitrakar, R. Yang, S. Li, D. Zhu, L. Chang*, Patchable Micro/nanodevice Interacting With Skin. Biosensors and Bioelectronics. 2018, 122, 189-204. (IF: 9.5) (一区Top)

6.       D. Li, Z. Wan, Y. Jiao, X. Ouyang, L. Chang*, X. Wang*, Bifunctional MoS2 coated melamine-formaldehyde Sponges for Efficient Oil-Water Separation and Water-Soluble Dye Removal. Applied Materials Today, 2017, 9, 551 -559. (IF: 8.0)

7.       W. Li, T. Kuang, X. Jiang, J. Yang, P. Fan, Z. Zhao, Z. Fei, M. Zhong, L. Chang*, F. Chen*, Photoresponsive Polyelectrolyte/Mesoporous Silica Hybrid Materials with Remote-Controllable Ionic Transportation. Chemical Engineering Journal. 2017. 322, 445- 453. (IF: 8.4) (一区Top)

8.       D. Gallego-Perez, D. Pal, S. Ghatak, V. Malkoc, N. Higuita-Castro, S. Gnyawali, L. Chang, W. Liao, J. Shi, M. Sinha, K. Singh, E. Steen, A. Sunyecz, R. Stewart, J. Moore, T. Ziebro, R. Northcutt, M. Homsy, P. Bertani, W. Lu, S. Roy, S. Khanna, C. Rink, V.B. Sundaresan, J. Otero, L.J. Lee*, C.K. Sen*, Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nature Nanotechnology. 2017, 12, 974-979 (IF: 33.4) (一区Top)

9.       L. Chang, F. Chen, X. Zhang, T. Kuang, M. Li, J. Hu, J. Shi, L.J. Lee, H. Chen, Y. Li, Synthetic Melanin E-ink. ACS Applied Materials & Interfaces. 2017, 9, 16553-16560.

(IF:8.5) (一区Top)

10.    T. Kuang#, L. Chang#*, X. Peng, X. Hu, D. Gallego-perez, Molecular beacon nano-sensors probing living cancer cells. Trends in Biotechnology. 2017, 35, 347-359. (IF: 13.7) (一区Top)

11.    L. Chang, L. Li, J. Shi, Y. Sheng, W. Lu, D. Gallego-Perez, L.J. Lee. Micro-/nano-scale electroporation. Lab Chip. 2016, 16, 4047-4062 (IF: 6.9) (一区Top)

12.    L. Chang, D. Gallego-perez, C. Chiang, P. Bertani, T. Kuang, F. Chen, Y. Sheng, Z. Chen, J. Shi, H. Yang, V. Malkoc, W. Lu, L.J. Lee, Controllable Large-scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform. Small. 2016, 12, 5971-5980.

(封面文章)(IF: 10.9) (一区Top)

13.    D. Gallego-Perez#, L. Chang#, J. Shi, J. Ma, S.H. Kim, X. Zhao, V. Malkoc, X. Wang, M. Minata, K.J. Kwak, Y. Wu, G. Lafyatis, W. Lu, D.J. Hansford, I. Nakano, L.J. Lee, On-chip clonal analysis of glioma stem cells motility and therapy resistance. Nano Letters. 2016, 16, 5326-5332. (IF: 12.3) (一区Top)

14.    L. Chang, P. Bertani, D. Gallego-Perez, Z. Yang, C.L. Chiang, V. Malkoc, L.J. Lee, W. Lu. 3D nanochannel electroporation for high-throughput cell transfection with high uniformity and dosage control. Nanoscale. 2016, 8, 243-252.

(Web of Science ESI高引论文)(封面文章)(年度HOT文章)

(OSU News报道)

(IF: 7.0) (一区Top)

15.    L. Chang, J. Hu, F. Chen, J. Shi, Z. Yang, Y. Li, L.J. Lee, Nanoscale bio-platforms for living cell interrogation: current status and future perspectives. Nanoscale. 2016, 8, 3138-3206. (IF: 7.0) (一区Top)

16.    T. Kuang#, L. Chang#, F. Chen, Y. Sheng, D. Fu, X. Peng, Facile preparation of lightweight high-strength biodegradable polymer nanocomposite foams for  electromagnetic interference shielding. Carbon. 2016, 105, 305-313. (IF: 7.5) (一区Top)

17.    L. Chang, M. Howdyshell, W. Liao, C. Chiang, D. Gallego-Perez, Z. Yang, J. Byrd, L. Wu, N. Muthusamy, L.J. Lee. R. Sooryakumar. Magnetic tweezer based 3D micro-electroporation system for high throughput transfection in living cells. Small. 2015, 11, 1818-1828.

(Web of Science ESI高引论文)

(IF: 10.9) (一区Top)

18.    L. Chang, D. Gallego-Perez, X. Zhao, P. Bertani, Z. Yang, C.L. Chiang,  V. Malkoc, C.K. Sen, L. Odonnell, J. Yu, W. Lu, L.J. Lee. Dielectrophoresis-assisted 3D Nanoelectroporation for Non-viral Cell Transfection in Adoptive Immunotherapy. Lab Chip. 2015, 15, 3147 – 3153.

(年度HOT文章) (IF: 6.9) (一区Top)

 

 

招聘、招生信息:

常凌乾博士,生物与医学工程学院教授,单细胞分析纳米技术研究所负责人。曾担任美国北德克萨斯大学助理教授,入选2017年中组部‘青年千人计划’。从事单细胞基因转染技术和细胞微操纵技术及其在细胞基因检测、治疗等领域的研究。近五年在国际期刊发表SCI论文50篇,如Nature Nanotechnology, Nano Letters, Small等。申请或授权美国专利3项,中国专利5项。兼任SCI期刊Biomedical Engineering Online副主编(Associate Editor)和Computers in Biology and Medicine编委(Editorial Board), Springer NatureElectroporation Protocol第三版主编。

 

目前课题组、研究所招聘以下三个方面的副研究员和博士后:

1.     动物在体实验(偏纳米技术在体应用);

2.     微纳米芯片设计和应用;

3.     细胞转染和基因探针设计

 

(1)     本科生科研助理倾向有意愿攻读硕博、勤劳踏实的大三大四本科生,有细胞实验经验者优先考虑,有推荐免试北航研究生可能者优先考虑;

(2)     已经录取北航生医学院或其他学院的硕士生、博士生,或在其他课题组,有意向与本研究所合作的研究生,请直接发CV到changlingqian1986@buaa.edu.cn

(3)     有资格申报卓越百人博士后者优先,CVchanglingqian1986@buaa.edu.cn

 

课题组发表论文情况: https://scholar.google.com/citations?user=ZPSmPvYAAAAJ&hl=en

个人网站:https://changlingqian.weebly.com/

 

单细胞分析纳米技术研究所公众号: