北京航空航天大学 生物与医学工程学院  教授/博士生导师

Jing DU, Ph.D. & Professor

School of Biological Science and Medical Engineering, Beihang University, Beijing, China

Awarded NSFC Excellent Young Scientists Fund

主要教育、科研简历：

2000－2004  北京大学医学部、药学学士学位

2004－2009  清华大学生物科学与技术系／医学院、生物学博士学位

2009－2011  清华大学航天航空学院、博士后

2011－2013  清华大学航天航空学院、讲师

2013－2017  清华大学航天航空学院、副教授

2013－2014  东京大学（日本）、客座研究员

2017－至今 北京航空航天大学生物与医学工程学院、长聘副教授、教授

Education / Professional Experience

2000－2004:      B.E., School of Pharmaceutical Sciences, Peking University, China 

2004－2009:      Ph.D., School of Medicine, Tsinghua University, China

2009－2011:      Postdoctoral RA, School of Aerospace, Tsinghua University, China

2011－2013:      Lecturer, School of Aerospace, Tsinghua University, China

2013－2017:      Associate Professor, School of Aerospace, Tsinghua University, China

2013－2014:      Visiting researcher, University of Tokyo, Japan

2017－Present:    Associate Professor,  Professor, School of Biological Science and Medical Engineering, Beihang University, China

主要研究方向:

1.细胞与分子力学生物学  2. 胚胎发育力学生物学  3.生物医学工程 4. 干细胞工程学

Research Interests

1. Cellular and molecular mechanobiology   2. Embryonic developmental mechanobiology   3. Biomedical engineering 4. Stem cell engineering

主要研究工作简介:

近年来，先后主持国家自然科学基金青年基金和面上项目等。长期从事胚胎发育力学生物学研究。针对胚胎模式形成与细胞命运决定的力学生物学调控机制问题，开展了跨尺度的交叉学科研究，揭示了从单细胞水平到多细胞群落，再到多层组织水平的力学生物学机制。在Cell Systems、PNAS、Advanced Science等相关领域发表SCI收录论文30余篇，获得国家发明专利2项。

社会兼职：

中国力学学会软物质力学工作组组员、

北京生物医学工程学会青年委员

主要教学工作简介:

  承担本科生和研究生专业课程的教学工作，主要包括《生物化学与分子生物学》、《遗传学》、《分子生物学》、《生物力学实验》、《多尺度生物力学》等课程。

部分论文列表（Publications Selected）:

1. Jialing Cao, Hangyu Li, Hongyan Tang, Xuenan Gu, Yan Wang*, Dongshi Guan*, Jing Du* and Yubo Fan* Stiff Extracellular Matrix Promotes Invasive Behaviors of Trophoblast Cells. Bioengineering 2023, 10, 384.
2. Tailin Chen, Wanjuan Bu, Jun Guo, Yuxiao Zhang, Min Tan, Jing Du *, Yubo Fan* Electroporation of embryonic chick skin explant. Medicine in Novel Technology and Devices 2022; 16: 100194
3. Tailin Chen, Yan Zhao, Xinbin Zhao, Shukai Li, Jialing Cao, Jun Guo, Wanjuan Bu, Hucheng Zhao, Jing Du*, Yanping Cao*, and Yubo Fan* Self-organization of Tissue Growth by Interfacial Mechanical Interactions in Multi-layered Systems. Advanced Science 2022, 2104301
4. Xin-Bin Zhao, Yun-Ping Chen, Min Tan, Lan Zhao, Yuan-Yuan Zhai, Yan-Ling Sun, Yan Gong, Xi-Qiao Feng, Jing Du*, and Yu-Bo Fan* Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-dependent Nuclear Transport of DNMT3L. Advanced Healthcare Materials 2021, 10(16): e2100821
5. Meihong Lu, Jialing Cao, Yuanyuan Zhai, Peng Zhao, Jie Yao, Yan Gong, Jing Du, Yubo Fan. T Soft Substrate and Decreased Cytoskeleton Contractility Promote Coupling and Morphology Maintenance of Pluripotent Stem Cells. Acta Mechanica Sinica. 2021, 37, 1520–1529
6. Xinbin Zhao, Yuecheng Ding, Jing Du*, Yubo Fan*. 2020 update on human coronaviruses: one health, one world. Medicine in Novel Technology and Devices 8:100043 (2020)

7.      Jing Du *, Yanlei Fan, Zheng Guo, Youguang Wang, Xu Zheng, Chong Huang, Baihui Liang, Lingyu Gao, Yanping Cao, Yunping Chen, Xi Zhang, Lei Li, Luping Xu, Congying Wu, David A. Weitz* and Xiqiao Feng* Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4. Cell Systems 2019, 9, 214–220

8.      Tailin Chen, Hucheng Zhao, Li Gao, Lichao Song, Fuchun Yang, Jing Du* Hypotonicity promotes epithelial gap closure by lamellipodial protrusion. Progress in Biophysics and Molecular Biology 2019, 148, 60

9.      Zi-Long Zhao^#, Zong-Yuan Liu^#, Jing Du, Guang-Kui Xu, and Xi-Qiao Feng A Dynamic Biochemomechanical Model of Geometry-Confined Cell Spreading. Biophysical Journal 2017, 112, 2377–2386

10.  Nana Luo, Jeffrey K. Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, Ruhong Zhou, Guanghui Ma PEGylated Graphene Oxide Elicits Strong Immunological Responses Despite Surface Passivation. Nature Communication 2017, 8, 14537

11.  Jing Du^#, Yan Zu^#, Jing Li, Shuyuan Du, Yipu Xu, Lang Zhang, Li Jiang, Zhao Wang, Shu Chien^*, Chun Yang^*, Extracellular matrix stiffness dictates Wnt expression through integrin pathway, Scientific Reports, 2016, 6:20395, doi:10.1038 / srep20395

12.  Jing Du*, Yanlei Fan, Tailin Chen, Xiqiao Feng, Lifeact and Utr230 induce distinct actin assemblies in cell nuclei, Cytoskeleton, 2015,72 (11): 570–575

13.  Yan Zu, Xudong Liang, Jing Du, Shuai Zhou, Chun Yang^*, Binding of integrin α1 to bone morphogenetic protein receptor IA suggests a novel role of integrin α1β1 in bone morphogenetic protein 2 signalling, Journal of Biomechanics, 2015, 48(14): 3950–3954

14.  Jing Du, Yan Zu, Yue Xu, Chun Yang^*, ECM Stiffness Regulates Integrin Activity via FAK/Raf Pathway in a Negative Feedback Manner, Progress in Biochemistry and Biophysics, 2014, 41(11): 1155-1162

15.  Guangkui Xu, Chun Yang, Jing Du, Xiqiao Feng^*, Integrin activation and internalization mediated by extracellular matrix elasticity: A biomechanical model, Journal of Biomechanics, 2014, 47(6):1479-1484

16.  Jing Du, Xiaofei Chen, Xudong Liang, Guangyao Zhang, Jia Xu, Linrong He, Qingyuan Zhan, Xi-Qiao Feng, Shu Chien^*, Chun Yang^*, Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity, PNAS, 2011, 108(23): 9466-9471