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Mechanical Characterization of Tissues and Biomaterials with Microstructure by Image-Based Deformation Measurements

Wei Tong （童玮）教授

时间：2011年5月17日（周二）上午10：00

地点：逸夫楼416学术报告厅

报告人简介：

童玮教授， 1985年毕业于中国科技大学，1991年毕业于美国布朗大学获应用力学博士，1991年-1994年曾在马萨诸塞州科技研究院、加利福尼亚科技研究院做博士后，1994-1996年在内布拉斯加大学任助理教授，1996年-2005年在耶鲁大学担任机械工程系助理教授及副教授，2001年受聘为布朗大学客座副教授，2005年到美国德克萨斯州南卫理公会大学机械工程系任教授，曾获得美国NSF Faculty Fellowship，NSF Young Faculty CAREER Award，Nebraska Research Initiative Award等多种奖项。主要研究：生物组织、生物材料以及相关生物工程应用中的力学现象，基于图像的全场位移和应变测量方法，在金属形成和延展性破坏中多晶体的粘性及其应用等。

报告简介：

Knowledge of mechanical properties of bones and porous biomaterials is important for designing bone replacements and implants as well as developing effective medical treatment of bone diseases such as osteoporosis. However, bone, especially trabecular bone, is a highly anisotropic and heterogeneous living tissue. Micro-computed-tomography (micro-CT) is used for nondestructive investigation of three-dimensional trabecular bone architecture. To link the bone micro-architecture and its mineral distribution gradients to overall mechanical response of trabecular bone, a finite element (FE) model is often constructed from the micro-CT voxel data of a representative cubic bone samples. The microstructure-based trabecular bone model, once validated, will be useful to aid the development of bone-implant interface optimization, radiation surgery treatment of certain spine cord diseases, and prevention of spine injury and hip fracture. In this talk, our on-going research effort in developing and validating a sample-specific micro-FE model of trabecular bone at continuum and mesoscopic levels will be described. In particular, a mechanical testing technique was developed for compressing the bone sample beyond its maximum strength with extensive 3D surface deformation mapping measurements. The results complement volumetric deformation mapping measurements based on micro-CT images and 3D ultrasound measurements of the same cubic samples and will be part of a comprehensive data base for validating the micro-FE model of trabecular bones.