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Advanced technologies for quantitative bone quality assessment and their applications

时间： 2012年6月21日（周四）下午14：30

地点：逸夫楼416学术报告厅

报告人简介：

PUNAM KUMAR SAHA obtained his Ph.D. degree in Computer Science and Engineering in 1997 from the Indian Statistical Institute, which he joined as a faculty member in 1993. Currently, he is working as an Associate Professor in Departments of ECE and Radiology, University of Iowa and directs the Structural Imaging Laboratory. His present research interests include biomedical imaging applications, trabecular bone imaging, computer vision and image processing, scale and class uncertainty theory, quantitative digital topology and geometry. He has published over 70 papers in international journals and over 150 papers/abstracts in international conferences. He received a Young Scientist award from the Indian Science Congress Association in 1996. He has served as an associate editor for Pattern Recognition and Computerized Medical Imaging and Graphics journals; currently, he is an Associate Editor of IEEE Transactions on Biomedical Engineering. He has served as a program committee member for several international conferences. He has received several grant awards from the National Institute of Health, USA.

报告简介：

Osteoporosis leads to low bone mineral density (BMD) and micro-architectural deterioration increasing fracture-risk. An effective and reliable measure of trabecular bone (TB) micro-architectural quality via in vivo imaging would be an important indicator of bone strength and fracture-risk for use in bone related clinical studies. Recently, a volumetric topological analysis (VTA) method was developed and a peripheral high resolution multi-row detector CT (MD-CT) bone imaging protocol was established in our laboratory toward in vivo assessment of bone health. The new method characterizes the topology of individual trabeculae on the continuum between a perfect plate and a perfect rod in a volumetric BMD representation of a TB network that will facilitate early detection, as well as characterization of bone alteration. The method also generates unique information that characterizes the BMD distribution over the continuum of TB plate-widths. The goal of this study is to evaluate the method’s performance under in vivo conditions at different radiation doses and to examine its feasibility in healthy human volunteers. VTA-based TB micro-architectural measures demonstrated high repeat MD-CT scan reproducibility (intra-class correlation coefficient or ) and high linear correlation () between MD-CT and micro-CT (µ-CT) scans in a cadaveric distal tibia study. VTA measures of TB micro-architecture from MD-CT scans under in vivo condition are stronger predictors () of the experimental mechanical properties of TB as compared to volumetric BMD (). The BMD/plate-width distribution improved ability of predicting TB’s yield stress to from as achieved by volumetric BMD. The performance analysis of the VTA method on cadaveric specimens at different radiation doses showed that the method can be used to assess human TB micro-architectural quality even at 50% reduction of the radiation dose currently being used. Experimental results of a small pilot in vivo study established the method’s feasibility to characterize human TB micro-architecture at a peripheral site. Finally, the method’s ability to detect physical activity effects on TB micro-architecture was examined in two pairs of healthy young volunteers.