报告题目：Developmental vasculogenesis mechanisms during embryogenesis and disease

 in vertebrates

报 告 人：Ramani Ramchandran, Ph.D.

地    点：逸夫科学馆416会议室

时    间：2010年4月12日，10:30

Ramani Ramchandran博士主要研究方向：

• 1. Developmental Vascular Biology: Vasculogenesis and Angiogenesis Mechanisms in Zebrafish and Mice

• 2. Vessel and Axon Guidance

• 3. Zebrafish Chemical Biology

• 4. Translational Zebrafish Models of Disease

Ramani Ramchandran, PhD 

TitlesInvestigator, Children's Research Institute; associate professor, Pediatrics, Medical College of Wisconsin.

DivisionGenetics

Research center/programCardiothoracic Surgery, Developmental Vascular Biology Program

Research interestsBirthmarks and vascular anomalies, cell and developmental biology

Study interestsAxon guidance, hemangiomas of infancy, vascular biology, zebrafish.

EducationDoctorate, Medical College of Georgia, Augusta, 1997; post-doctoral fellowship, Harvard Medical School, Boston, 1997-2002.

HonorsBatliboi Scholarship Award (bachelor's degree), 1990; Batliboi Scholarship Award (master's degree), 1991; Tata Memorial Scholarship Award, 1992; Graduate Research Assistantship Award, 1992; Third place, Sigma XI, 1997; Listed in "Who's Who Among Students in American Universities and Colleges," 1997; Special Recognition Award from Student Government Association, 1997; Ruth L. Kirchstein National Research Service Award, 2001; National Cancer Institute Scholar Award, 2002; Nominated for Outstanding Mentor Award, NCI, National Institutes of Health, 2004; Listed in Madison, Wis., "Who's Who of Business Leaders and Professionals," 2006; Cash Performance Award, NIH, 2006.

Representative publications

• Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP. Critical Roles of CDI46 in Zebrafish Vascular Development. Developmental Dynamics. 2005; 232:232-44.
• Bedell V, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond I, Li DY, Ramchandran R. Roundabout4 is Essential for Angiogenesis in vivo. Proceedings of the National Academy of Science. 2005; 102:6373-78.
• Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R. Robo4 Signaling in Endothelial Cells Imply Attraction Guidance Mechanisms. Journal of Biological Chemistry. 2006; 281(16):11347-56.
• Hu G, Tang J, Zhang B, Lin Y, Hanai JJ, Galloway J, Bedell VM, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP. HSPA12B is Essential in Zebrafish Vascular Development. Journal of Cell Science. 2006; 119:4117-26.
• Arbiser JL, Kau T, Konar M, Narra K, Ramchandran R, Summers SA, Vlahos CJ, Ye K, Perry BN, Matter W, Fischl A, Coolk J, Silver PA, Bain J, Cohen P, Whitmire D, Furness S, Govindarajan B, Bowen P. Solenopsin, the Alkaloidal Component of the Fire Ant (Solenopsis invicta), is a Naturally Occurring Inhibitor of Phosphatidylinositol-3-kinase Signaling and Angiogenesis. Blood. 2007; 109(2):560-5.
• Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC. Cloning and Characterization of Zebrafish (Danio rerio) Cyclin Dependent Kinase 5. Neuroscience Letters. 2006.

Grants

• National Cancer Institute Scholar Award, principal investigator, National Institutes of Health, 2002-2009.
• Cloche: A Basic and Translational Model for Cardiovascular Disease, principal investigator, 2008-2011.
• Roundabout4 Signaling in Endothelial Cells, principal investigator 2009-2013.
• Fully Automated Angiogenesis Drug Discovery Assay in Zebrafish, 2009-2010