血栓与止血异常可导致中风、心肌梗死等威胁人类健康的严重疾病，也是在太空微重力等特殊环境条件下，危及人类生存、健康的因素之一。本实验室主要从事血栓与止血、细胞信号转导和空间生理学研究，重点集中在三个方向：（1）血小板主要粘附受体的生理调控和细胞信号转导机制研究；（2）特殊重力环境下（微重或超重）人体生理功能的改变及其分子和细胞生物学机制研究；（3）抗血栓与止血药物及防治措施研究。

    本实验室拥有细胞生物学、分子生物学、血小板功能和空间生命科学研究的实验平台。可从事基因、蛋白和细胞水平的生物学研究。承担国家自然科学基金、教育部优博论文获得者专项基金、教育部新世纪优秀人才支持计划、教育部留学回国人员启动基金等多项科研任务。

    近年发表部分代表性论文：

    1.Kesheng Dai, Richard J. Bodnar, Michael C. Berndt, Xiaoping Du. A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications. Blood 2005, 106 (6): 1975-1981.

    2. Kesheng Dai, Yuedan Wang, Rong Yan, Quanwei Shi, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Suping Li, Yubo Fan, Fengyuan Zhuang. Effects of microgravity and hypergravity on platelet function.Thrombosis and Haemostasis 2009, 101(5): 902-910.

    3. Kesheng Dai, Rong Yan, Suping Li, Yubo Fan, Fengyuan Zhuang, Changgeng Ruan. Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIba shedding. Thrombosis Research 2009, 124 (1): 101-109.

    4.  Rong Yan, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Kesheng Dai. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Archives of Biochemistry and Biophysics 2009, 485(1): 41-48.

    5. Suping Li, Quanwei Shi, Zhicheng Wang, Rong Yan, Hong Cheng, Kesheng Dai. Hypergravity Results in Human Platelet Hyperactivity. Journal of Physiology and Biochemistry 2009, 65(2): 147-156.

    6. Hong Cheng, Suping Li, Yanhong Yuan, Rong Yan, Kesheng Dai. Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibα shedding, The American Journal of Physiology-Heart and Circulatory Physiology. 2009, (in press).