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邓小燕 博士
北京航空航天大学 生物与医学工程学院 教授
北航首届十佳“教书育人”优秀研究生导师
Xiaoyan Deng, Ph.D. & Professor
School of Biological Science and Medical Engineering, Beihang University, Beijing
Email：dengxy1953@buaa.edu.cn
课题组承担血流动力学、细胞生物力学、人工器官和血管植/介入器械相关课题，欢迎生物医学工程、生物、力学、机械等相关专业学生报考研究生。
主要教育、科研简历
主要教育经历
1991 加拿大麦吉尔大学 (McGill University)，化学工程系及临床研究所，生物
医学工程专业博士
1982 成都科技大学，工程力学系，生物力学专业硕士
1975 武汉华中理工大学，火电站专业本科专业
主要工作经历
2008—至今 北京航空航天大学生物与医学工程学院 教授，博导
2005—2008 北京航空航天大学生物工程系 教授，博导，
2002—2004 重庆大学生物工程学院 教授，博导，院长
2000—2002 大连理工大学工程力学系 教授，博导
1995—2000 加拿大魁北克拉瓦尔大学生物材料研究所 研究员
加拿大魁北克拉瓦尔大学医学院外科系 科研教授
1991—1995 加拿大魁北克拉瓦尔大学生物材料研究所 博士后
1983—1985 成都科技大学 （现四川大学） 工程力学系 助教
1978—1980 四川省环境保护研究所 助理工程师
1975—1978 西南核反应堆研究设计院（二机部第一设计院） 反应堆操纵员
Education
10/1991 Ph.D., Biomedical Engineering, Department of Chemical Engineering,
McGill Medical Clinic, McGill University, Montreal, Canada
12/1982 M.S., Biomechanics, Department of Engineering Mechanics, Chengdu
University of Science and Technology, Chengdu, China
10/1975 Graduation, Power Station, Huazhong University of Science and
Technology, Wuhan, China
Professional Experience
2005-Present Professor, School of Biological Science and Medical Engineering,
Beihang University, China
2002-2004 Professor and Dean, College of Bioengineering,
Chongqing University, Chongqing, China
2000-2002 Professor, Dalian University of Technology, Dalian, China
1995-2000 Senior Researcher and Research Professor (Professeur Asscié),
Department of Surgery and Quebec Biomaterials Institute,
Laval University, Canada
1991-1995 Postdoctoral Fellow, Quebec Biomaterials Institute,
Laval University, Canada
1983-1985 Assistant Professor, Department of Engineering Mechanics,
Chengdu University of Science and Technology, Chengdu, China
1978-1980 Engineer, Sichuan Provincial Environment Protection Research
Institute, Chengdu, China
1975-1978 Nuclear Reactor Operator, South-West Nuclear Reactor Research
Center of China, China
主要研究方向
血流动力学
心血管介入器械与人工器官
细胞生物力学与力生物学
Research Interests
Hemodynamics
Cardiovascular Implants and Devices
Cell Biomechanics and Mechanobiology
主要社会兼职
中国生物医学工程学会(第六届) 理事
中国生物物理学会生物力学及生物流变学专业委员会 委员
生物力学专业委员会(第五届) 副主任
生物力学专业委员会(第六届) 委员
《生物物理学报》 编委
《医用生物力学》 编委
《生物医学工程学杂志》 编委
《力学学报》（英文版） 编委
Memberships of Professional Societies
Council Member of the 6th Chinese Biomedical Engineering Society
Council Member of the Biomechanics and Biorheology Committee
Committee member (Vice Chairman) of the 5th China Society of Biomechanics
Member of Editorial Board
Editorial Board Member of “Journal of Medical Biomechanics” (Chinese), “Acta Biophysica Sinica”, “Journal of Medical Biomechanics (Chinese)” and “Acta Mechanica Sinica”
近五年作为通讯作者发表的SCI论文（Recent Five-year Publications as Corresponding Author）
(1) Fan Z, Liu X, Du C, et al. Plaque components affect wall stress in stented human carotid artery: a numerical study[J]. Acta Mechanica Sinica, 2016: (ahead of print).
(2) Hongyan Kang, Lianwen Sun, Yunfei Huang, Zhenze Wang, Ping Zhao,Yubo Fan,Xiaoyan Deng. Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats. Pflugers Arch - Eur J Physiol (2015) 467:1291–1301
(3) Anqiang Sun, Zhenze Wang, Zhenmin Fan, Xiaopeng Tian, Fan Zhan, Xiaoyan Deng,Xiao Liu. Influence of proximal drug eluting stent (DES) on distal bare metal stent (BMS) in multi-stent implantation strategies in coronary arteries. Medical Engineering and Physics 37 (2015) 840–844.
(4) Xiao Liu, Min Wang, Nan Zhang, Zhanming Fan, Yubo Fan,Xiaoyan Deng. Effects of endothelium, stent design and deployment on the nitric oxide transport in stented artery: a potential role in stent restenosis and thrombosis. Med Biol Eng Comput (2015) 53:427–439
(5) Xue Yan, Liu Xiao, Sun Anqiang, Zhang Peng, Fan Yubo, Deng Xiaoyan . Hemodynamic Performance of a New Punched Stent Strut: A Numerical Study[J]. Artificial Organs, 2015.
(6) Sun Anqiang , Tian Xiaopeng, Zhang Nan, Xu Zaipin, Deng Xiaoyan, Liu Ming and Liu Xiao. Does lower limb exercise worsen renal artery hemodynamics in patients with abdominal aortic aneurysm?[J]. PloS one, 2015, 10(5).
(7) Zhang P, Liu X, Sun AQ, Deng XY. Hemodynamic insight into overlapping bare-metal stents strategy in the treatment of aortic aneurysm. J Biomech. 2015, 48:2041-2046.
(8) Liu X, Sun AQ, Fan YB, Deng XY. Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications. Ann Biomed Eng. 43(4):3-15 (2015)
(9) Sun AQ, Wang ZZ, Zhan F, Xu ZP, Deng XY. A New Way to Optimize Drug Release Rate of Drug Eluting Stent (Des). Journal of Mechanics in Medicine and Biology. 2015: 1550064.
(10) Chen ZS, Zhan, F, Ding J, Zhang XW, Deng XY. A new stent with streamlined cross-section can suppress monocyte cell adhesion in the flow disturbance zones of the endovascular stent. Comput Methods Biomech Biomed Engin. (2014，online)
(11) Wang ZZ, Liu X, Kang HY, Sun AQ, Fan YB, Deng XY. Effect of shear stress on water and LDL transport through cultured endothelial cellmonolayers Enhanced accumulation of LDLs within the venous graft wall induced by elevated filtration rate mayaccount for its accelerated atherogenesis. Atherosclerosis 236(1):198-206 (2014)
(12) Zhang P, Sun AQ, Zhan F, Luan J, Deng XY. Hemodynamic study of overlapping bare-metal stents intervention to aortic aneurysm. J Biomech. 47(14):3524-30 (2014)
(13) Liu X, Wang ZZ, Zhao P, Fan ZM, Sun AQ, Zhan F, Fan YB, Deng XY. Nitric oxide transport in normal human thoracic aorta: effects of hemodynamics and nitricoxide scavengers. PLoS One 9(11):e112395(2014)
(14) Kang HY, Sun LW, Huang YF, Wang ZZ, Zhao P, Fan YB, Deng XY. Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats. Pflugers Arch. DOI: 10.1007/s00424-014-1568-1 (2014)
(15) Kang HY, Liu ML, Fan YB, Deng XY. A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation. Astrobiology 13(7):626-36 (2013)
(16) Liu X, Fan YB, Sun AQ, Deng XY. Numerical simulation of nucleotide transport in the human thoracic aorta. J Biomech. 46(4):819-27 (2013)
(17) Fan ZM, Sun AQ, Liu X, Fan YB, Zhao P, Deng XY.The accelerated atherogenesis of venous grafts might be attributed to aggravated concentration polarization of low density lipoproteins: A numerical study. J Biomech 46(14):2388-93 (2013)
(18) Kang HY, Fan YB, Sun AQ, Jia XL, Deng XY. Simulated Microgravity Exposure Modulates the Phenotype of Cultured Vascular Smooth Muscle Cells. Cell Biochem Biophys. 66(1):121-30 (2013)
(19) Sun AQ, Fan YB, Deng XY. Intentionally induced swirling flow may improve the hemodynamic performance of coronary bifurcation stenting. Catheterization and Cardiovascular Interventions 79:371–377 (2012)
(20) Ding ZF, Liu SJ, Yang B, Fan YB, Deng XY. Effect of oxidized low-density lipoprotein concentration polarization on human smooth muscle cells' proliferation, cycle, apoptosis and oxidized low-density lipoprotein uptake. Journal of the Royal Society Interface. 2012 Jun; 9(71):1233-40.
(21) Zhan F, Fan YB, Deng XY. Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end- to- end anostomoses. Acta Mechanica Sinica 2011;27 (5):833-839.
(22) Liu X, Fan YB, Deng XY, Zhan F. Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta. Journal of Biomechanics 2011;44:1123-1131.
(23) Liu X, Fan YB, Deng XY. Effect of the endothelial glycocalyx layer on arterial LDL transport under normal and high pressure. Journal of Theoretical Biology 2011;283(1):71-81.
(24) Liu X, Fan YB, Deng XY. Mechanotransduction of Flow-Induced Shear Stress by Endothelial Glycocalyx Fibers is Torque Determined. ASAIO Journal 2011;57(6):487-94.
(25) Chen ZS, Fan YB, Deng XY. A novel deployment design of vena cava filters might be the solution to their blockage problem. Medical Hypotheses 2011;77(6):990-2.
(26) Chen ZS, Fan YB, Deng XY, Zhai XP. A New Way to Reduce Flow Disturbance in Endovascular Stents: A Numerical Study. Artificial Organs 2011;35(4):392-7.
(27) Chen ZS, Fan Z, Fan YB, Deng XY. A novel way to reduce thrombus build-up in vena cava filters. Catheterization and Cardiovascular Interventions 2011;78(5):792-8.
(28) Kang HY, Fan YB, Deng XY. Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration and NO production responses. Am J Physiol Heart Circ Physiol 2011;300(1):H76-83.
(29) Kang HY, Fan YB, Sun AQ, Deng XY. Compositional or charge density modification of the endothelial glycocalyx accelerates flow-dependent concentration polarization of low-density lipoproteins. Experimental Biology and Medicine 2011;236(7):800-7.
(30) Zhou J, Lin J, Zhou CH, Deng XY, Xia B. Cytotoxicity of red fluorescent protein DsRed is associated with the suppression of Bcl-xL translation. FEBS Letters 2011;585:821-827.
(31) Zhou J, Lin J, Zhou CH, Deng XY, Xia B. An improved bimolecular fluorescence complementation (BiFC) tool based on super-folder GFP. Acta Biochimica et Biophysica Sinica 2011;43: 239–244.
(32) Wen J, Zheng TH, Jiang WT, Deng XY, Fan YB. A comparative study of helical-type and traditional-type artery bypass grafts: numerical simulation. ASAIO Journal 2011;57(5):399-406
(33) Liu X, Fan YB, Deng XY. Effect of spiral flow on the transport of oxygen in the aorta: a numerical study. Ann Biomed Eng 2010;38(3):917-926.
(34) Sun AQ, Fan YB, Deng XY. Numerical comparative study on the hemodynamic performance of a new helical graft with noncircular cross section and swirl graft. Artificial organs 2010;34(1):22-27
(35) Sun AQ, Fan YB, Deng XY, Xu ZP. Hemodynamic performance of a sutureless anastomosis device (the Graft Connector): A numerical study. International Journal of Artificial Organs 2010;33(6):392-398
(36) Ding ZF, Fan YB, Deng XY. Concentration polarization of oxidative modification of low-density lipoproteins: its effect on oxidative modification of low-density lipoprotein uptake and apoptosis of the endothelial cells. ASAIO JOURNAL 2010;56(5):468-474
(37) Ding ZF, Fan YB, Deng XY, Zhan F, Kang HY. Effect of swirling flow on the uptakes of native and oxidized LDLs in a straight segment of the rabbit thoracic aorta. Experimental Biology and Medicine 2010;235:506-513
(38) Ding ZF, Fan YB, Deng XY, Sun AQ, Kang HY. 3,3 '-Dioctadecylindocarbocyanine-low-density lipoprotein uptake and flow patterns in the rabbit aorta-iliac bifurcation under three perfusion flow conditions. Experimental Biology and Medicine 2010;235:506-513
(39) Zhan F, Fan YB, Deng XY, Xu ZP. The beneficial effect of swirling flow on platelet adhesion to the surface of a sudden tubular expansion tube: its potential application in end-to-end arterial anastomosis. ASAIO J 2010;56(3):172-179
(40) Zhan F, Fan YB, Deng XY. Swirling flow created in a glass tube suppressed platelet adhesion to the surface of the tube: its implication in the design of small-caliber arterial grafts. Thrombosis Research 2010;125(5):413-418
专利：
1 孙安强, 邓小燕, 樊瑜波, 贡向辉. 一种带有偏流导引器的人造血管. 专利号：ZL2008102229630. 授权公告日：20110504
2 孙安强，邓小燕，樊瑜波. 一种血管吻合器. 专利号：ZL2009100820283. 授权公告日：20110504
3 陈增胜，邓小燕，樊瑜波. 一种腔静脉滤器. 申请号：201110113707.X. 申请日：20110504
4 陈增胜，邓小燕，樊瑜波. 一种腔静脉滤器. 申请号：201110121164.6. 申请日：20110511
5 陈增胜，邓小燕，樊瑜波. 一种能实现零角度搭桥的人造血管. 申请号：201110135993.X. 申请日：20110524
6 孙安强，邓小燕，樊瑜波. 一种左心辅助装置. 申请号：201110162363.1. 申请日：20110616
7 陈增胜，邓小燕，樊瑜波. 一种流线型截面细丝组成的螺旋支架. 申请号：201010164474.1. 申请日：20100429
8 滕晓晶，邓小燕，樊瑜波. 一种血管内支架旋流导引装置. 申请号：200810225541.9. 申请日：20081105
9 陈颖，邓小燕，樊瑜波. 旋动流式腔静脉滤器. 申请号：200810226224.9. 申请日：20081110
10 孙安强, 邓小燕, 樊瑜波, 王振泽, 占帆, 刘肖. 药物涂层支架.申请号：201210033679.5
11 孙安强, 邓小燕, 樊瑜波, 王振泽, 占帆, 刘肖. 一种药物涂层支架.申请号：201210034036.2
12 孙安强, 邓小燕, 樊瑜波, 刘肖, 占帆, 王振泽.一种覆膜支架.申请号：201210033984.4
13 邓小燕, 王振泽, 刘肖, 孙安强. 一种血管支架. 申请号：201410349942
课题组承担的课题
1 国家自然科学基金重点项目，血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究(11332003), 2014.01-2018.12
2 国家自然科学基金重点项目，动脉系统中的旋动流现象-它对血小板运动、粘附和物质（LDL）输运的影响及其在临床中的应用(10632010), 2007.1-2010.12
3 国家自然科学基金面上项目，动脉系统中脂质的浓度极化与脂质在血管内皮层中沉积的相关性研究(30670517), 2007.1-2009.12
4 国家自然科学基金面上项目，血管内皮细胞糖萼形态结构变化与动脉系统中脂质浓度极化的相关性研究(11072023), 2011.1-2013.12
5 国家自然科学基金面上项目，血管内脂质的浓度极化与血管搭桥术后静脉血管老化（加速粥样硬化）现象的相关性研究(31170904), 2012.1-2015.12
6 国家自然科学基金面上项目，动脉系统旋动流在抑制动脉粥样硬化中所起生理作用的研究(11572028), 2016.01-2019.12
7 国家自然科学基金面上项目，腹主动脉瘤修复术后发生在膨大的生物力学机理研究(11472031), 2015.01-2018.12
8 国家自然科学基金面上项目，一氧化氮在动脉中的输运规律及其与动脉粥样硬化局部性现象的相关性研究 (31570947), 2016.01-2019.12
9 国家自然科学基金青年科学基金项目，糖萼作为力感受器在模拟失重致大鼠动脉血管功能重建中的作用研究(31500763), 2016.01-2018.12
10 国家自然科学基金青年科学基金项目，流动刺激下，内皮细胞糖萼介导的力传导与内皮细胞出芽（血管新生）的相关性研究(31200703), 2013.01- 2015.12
11 国家自然科学基金青年科学基金项目，腹主动脉瘤修复引起肾动脉狭窄和肾功能异常的血流动力学研究(11102014), 2012.1-2014.12
12 国家自然科学基金海外及港澳学者合作研究基金，人体冠脉分叉处血管支架介入治疗的血流动力学研究(11228205), 2013.01-2014.12
课题组主要成员
主要从事血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究。
E-Mail:chenying120@163.com
联系方式:
地址：北京、北京航空航天大学、生物与医学工程学院,100191
电子邮件： dengxy1953@buaa.edu.cn
Contact Information:
Address: School of Biological Science and Medical Engineering, Beihang University. Xueyuan Road No.37, HaiDian District, Beijing, 100191, China
Email: dengxy1953@buaa.edu.cn
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