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Scientific research

Regenerative Medicine and Tissue Engineering

Base on the fundamental principles of life sciences and engineering, we develop biological substitutes to restore, maintain and improve tissue functions. Research of this field focuses on the following directions: the fundamental and clinical problems in the repair and regeneration of central nervous system, such as brain and spinal cord; the effect of microenvironmental factors, such as the extracellular matrix protein components, geometric properties and mechanical properties on stem cell behavior, and the regeneration of skeleton muscle and the molecular mechanism; using the micro-patterning and micro-bioreactor technology to study the intrinsic mechanism of vascular diseases such as atherosclerosis, especially focusing on the regulation of endothelial cell function by the direction and pattern of blood flow; development and application of 3D bio-printing; molecular modeling of nano-biointerfaces and nano-technology for single-cell analysis.


  1. Alteration of brain regional homogeneity of monkeys with spinal cord injury: A longitudinal resting-state functional magnetic resonance imaging study
  2. Calcium Hydroxide-induced Proliferation, Migration, Osteogenic Differentiation, and Mineralization via the Mitogen-activated Protein Kinase Pathway in Human Dental Pulp Stem Cells
  3. Compositional or charge density modification of the endothelial glycocalyx accelerates flow-dependent concentration polarization of low-density lipoproteins
  4. Effect of Fluid Shear Stress on Cardiomyogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells
  5. Effect of shear stress on water and LDL transport through cultured endothelial cell monolayers
  6. Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury: A resting-state fMRI study
  7. High glucose-induced endothelial progenitor cell dysfunction
  8. Vascular Cell Glycocalyx-Mediated Vascular Remodeling Induced by Hemodynamic Environmental Alteration
  9. Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration, and NO production responses