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教育、工作经历:
2003-2011:北京大学 临床医学(八年制本博连读) 临床医学学士、临床医学博士
2011-2013:首都医科大学附属北京同仁医院 眼科医师
2013-今: 北京航空航天大学生物与医学工程学院 讲师、副教授,硕导、博导
2016-2017:美国杜克大学生物医学工程系 访问学者
Education & Professional Experience:
2003-2011 M.B. to M.D. Peking University, Clinical Medicine(8-year program)
2011-2013 Resident Department of Ophthalmology, Beijing Tongren Hospital
2013-Present Assistant Professor, Associate professor, Master Supervisor, Doctoral Supervisor
aSchool of Biological Science and Medical Engineering, Beihang University
2016-2017 Visiting Scholar Department of Biomedical Engineering, Duke University
教学情况:
主讲4门本科生核心专业课程和1门研究生必修课,其中“医学伦理学”认证为校级一流本科课程、校级课程思政示范课,“解剖生理学”、“临床医学基础与医学伦理”认证为校级一流本科课程、双百工程优质课程。主持多个校级教改项目,获校级优秀主讲教师、凡舟奖教金、校级优秀教学成果奖一等奖等荣誉。
人才培养:
获校级优秀硕士学位论文指导教师,培养毕业多名本科生及研究生。指导大学生创新创业训练计划项目4项,指导本科生获校级优秀毕业生、冯如杯竞赛多项奖项;指导研究生获北京市优秀毕业生、中国生物医学工程大会优秀论文竞赛(研究生)一等奖、北京航空航天大学优秀硕士学位论文、北京航空航天大学“优秀毕业生”,学生一作发表中科院Top期刊多篇,论文获国内外顶刊顶会“Top View Papers award”、优秀论文、优秀海报奖等荣誉。
主要研究方向:
1. 眼相关疾病的力学生物学发病机制研究
2. 促角膜再生修复的药物及生物材料研发
3. 细胞力学转导的分子机制研究
Research Interests:
1. Ocular Biomechanics & Mechanobiology
2. Corneal Regenerative Medicine
3. Molecular Mechanisms of Cellular Mechanotransduction
主要科研项目:
1. 国家自然科学基金面上项目,细胞粘附分子在渗透压调控角膜上皮损伤修复中的作用及其机制研究,12472316,主持
2. 国家自然科学基金重点项目(子课题),Laplace压力对细胞胞质分裂过程的调控,12232019,主持
3. 国家自然科学基金青年项目,力学刺激对角膜成纤维细胞生长状态及细胞因子分泌的影响研究,11402017,主持
4. 国家重点研发计划项目课题,复合型人工角膜生物愈合及生物力学关键技术研究,2023YFC2410404,骨干
5. 国家重点研发计划重点专项项目,物理剂量-生物学效应方法学与实验研究,2017YFC0108505,骨干
6. 国家重点实验室开放课题,化学交联对角膜黏合强度影响的研究,主持
7. 北京市自然科学基金重点研究专题,基于力电多物理刺激的角膜内皮修复材料与细胞作用的力学生物学机制,Z240017,主持
8. 北京航空航天大学敢为计划面上项目,微纳米颗粒复合miRNA促进角膜损伤修复的应用研究,JK2024-80,主持
9. 北京航空航天大学“蓝天新秀”计划,主持
近期主要论著(Recent Publications):
[1] Yilin Zhang#, Dongyan Li#, Hui Xiao, Xiuyuan Luo, Yi Xie, Sen Hou, Lizhen Wang, Yubo Fan, Jing Ji*, Linhao Li*. Janus silk-based patch with temporary adhesion for inflammatory mediators removal in corneal alkali burn treatment. Biomaterials, 2026, 330:124032.
[2] Long Li#, Jing Ji#, etc., Chunqiu Zhang*, Min Zhang*, Jizhong Lou*, Youhua Tan*, Linhong Deng*, Mian Long*, YingXin Qi*, Weiyi Chen*, Feng Xu*, Yubo Fan*, Fan Song*, Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine, The Innovation, 2026, 101307.
[3] Ruotian Du, Jing Ji*, Dongyan Li, Long Li*, Fan Song, Yubo Fan*. Mechanotransduction in trabecular meshwork cells: Rho/ROCK-Dependent responses to substrate stiffness. Journal of Biomechanics, 2026, 198:113164.
[4] Dongyan Li, Ruotian Du, Jilong Li, Yi Xie, Yan Huang, Xianghui Gong*, Jing Ji*. Integrin β1 mediates mechanosensitive regulation of human trabecular meshwork cell functions in response to substrate stiffness, European Journal of Cell Biology, 2026,105:151530.
[5] Ruotian Du#, Yizhuo WU#, Min Zou, Meiying Luo, Yan Li, Yingfeng Shao, Jing Ji*, Fan Song*, Long Li*, Intracellular Pressure: Regulation, Characterization and Implication. SCIENCE CHINA Physics, Mechanics & Astronomy, 2025, 68(8):288701.
[6] Meiying Luo#, Xiaohuan Wang#, Guoji Yu, Jing Ji*, Long Li*, Fan Song*. Development of a bispecific antibody-drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors, Experimental Hematology & Oncology, 2025,14(1):33.
[7] Dongyan Li, Jing Ji*, Xinyue Li, Yi Xie, Yan Huang, Junzhi Qin, Xili Ding*, Lizhen Wang, Yubo Fan*, LNP-encapsulated miRNA29b for corneal repair: A novel approach to combat fibrosis, Materials Today Bio, 2025, 32:101695.
[8] Shudong Zhao#, Sen Hou#, Dongyan Li, Linhao Li, Xili Ding, Yan Huang, Yuqi Li, Jing Ji*, Lizhen Wang*, Yubo Fan*. Injectable Magnetic Hyaluronic Acid Gel for Corneal Endothelial Cells Efficient Delivery and Retention. Applied Materials Today, 2024,37:102090.
[9] Long Li, Ruihan Hou, Xinghua Shi, Jing Ji*, Bartosz Rozycki*, Jinglei Hu*, Fan Song. Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography. Communications Physics, 2024,7:174.
[10] Long Li, Jing Ji*, Fan Song, Jinglei Hu*. Intercellular receptor-ligand binding: effect of protein-membrane interaction. Journal of Molecular Biology, 2023, 435(1):167787.
[11] Ruotian Du, Long Li*, Jing Ji*, Yubo Fan. Receptor–ligand binding:effect of mechanical factors. International Journal of Molecular Sciences, 2023, 24(10):9062.
[12] Ruotian Du, Dongyan Li, Meng Zhu, Lisha Zheng, Keli Ren, Dong Han, Long Li*, Jing Ji*, Yubo Fan*. Cell senescence alters responses of porcine trabecular meshwork cells to shear stress. Frontiers in Cell and Developmental Biology, 2022,10:1083130.
[13] Ruotian Du, Dongyan Li, Yan Huang, Hui Xiao, Jindong Xue, Jing Ji*, Yun Feng*, Yubo Fan*. Effect of mechanical stretching and substrate stiffness on the morphology, cytoskeleton and nuclear shape of corneal endothelial cells. Medicine in Novel Technology and Devices, 2022, 16:100180.
[14] Long Li, Jinglei Hu*, Bartosz Rozycki*, Jing Ji*, Fan Song. Interplay of receptor-ligand binding and lipid domain formation during cell adhesion. Frontiers in Molecular Biosciences, 2022,9:1019477.
[15] 姚菲菲, 汲婧*, 樊瑜波*. 渗透压对眼部细胞影响的研究进展. 医用生物力学, 2025, 40(06): 1646-1654.
[16] 肖辉, 李冬妍, 汲婧*, 王丽珍. 生物材料促进角膜碱烧伤修复的作用机制和应用途径. 中国组织工程研究, 2025,(10):2162-2170.
[17] 李冬妍,汲婧*,樊瑜波*. 小梁网弹性变化与青光眼发病的关系. 医用生物力学,2022,37(6):1171-1176.
[18] 付一凡,汲婧*. 咽鼓管功能障碍疾病模型研究进展. 中华耳科学杂志, 2022,20(4):814-818.
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