教授
邓小燕

职务职称:教授、博导
办公地点:逸夫馆412
联系电话:13371690898
E-Mail: dengxy1953@buaa.edu.cn
 

邓小燕 博士

 

北京航空航天大学 生物与医学工程学院 教授

 

北航首届十佳“教书育人”优秀研究生导师

 

Xiaoyan Deng, Ph.D. & Professor


School of Biological Science and Medical Engineering, Beihang University, Beijing
Email:
dengxy1953@buaa.edu.cn

 

课题组承担血流动力学、细胞生物力学、人工器官和血管植/介入器械相关课题,欢迎生物医学工程、生物、力学、机械等相关专业学生报考研究生。

主要教育、科研简历

主要教育经历

1991   加拿大麦吉尔大学 (McGill University),化学工程系及临床研究所,生物

       医学工程专业博士

1982    成都科技大学,工程力学系,生物力学专业硕士  

1975   武汉华中理工大学,火电站专业本科专业

 

主要工作经历

2008至今  北京航空航天大学生物与医学工程学院          教授,博导

20052008  北京航空航天大学生物工程系                  教授,博导,

20022004  重庆大学生物工程学院                        教授,博导,院长

20002002  大连理工大学工程力学系                      教授,博导

19952000  加拿大魁北克拉瓦尔大学生物材料研究所        研究员

            加拿大魁北克拉瓦尔大学医学院外科系          科研教授

19911995  加拿大魁北克拉瓦尔大学生物材料研究所        博士后

19831985  成都科技大学 (现四川大学)  工程力学系     助教

19781980  四川省环境保护研究所                        助理工程师

19751978  西南核反应堆研究设计院(二机部第一设计院)  反应堆操纵员

 

Education

10/1991    Ph.D., Biomedical Engineering, Department of Chemical Engineering,

                McGill Medical Clinic, McGill University, Montreal, Canada

12/1982    M.S., Biomechanics, Department of Engineering Mechanics, Chengdu

                University of Science and Technology, Chengdu, China

10/1975    Graduation, Power Station, Huazhong University of Science and

                Technology, Wuhan, China

                 

Professional Experience

2005-Present   Professor, School of Biological Science and Medical Engineering,

                      Beihang University, China

2002-2004      Professor and Dean, College of Bioengineering,

                     Chongqing University, Chongqing, China

2000-2002      Professor, Dalian University of Technology, Dalian, China

1995-2000      Senior Researcher and Research Professor (Professeur Asscié),

                     Department of Surgery and Quebec Biomaterials Institute,

                     Laval University, Canada                    

1991-1995     Postdoctoral Fellow, Quebec Biomaterials Institute,

                     Laval University, Canada

1983-1985     Assistant Professor, Department of Engineering Mechanics,

                    Chengdu University of Science and Technology, Chengdu, China

1978-1980     Engineer, Sichuan Provincial Environment Protection Research

                    Institute, Chengdu, China

1975-1978     Nuclear Reactor Operator, South-West Nuclear Reactor Research

                    Center of China, China

 

主要研究方向

 

血流动力学

心血管介入器械与人工器官

细胞生物力学与力生物学

 

Research Interests

    

Hemodynamics

Cardiovascular Implants and Devices

Cell Biomechanics and Mechanobiology

 

主要社会兼职

中国生物医学工程学会(第六届)                    理事

中国生物物理学会生物力学及生物流变学专业委员会  委员

生物力学专业委员会(第五届)                      副主任

生物力学专业委员会(第六届)                      委员

《生物物理学报》                                编委

《医用生物力学》                                编委

《生物医学工程学杂志》                          编委

《力学学报》(英文版)                          编委

 

Memberships of Professional Societies

 

Council Member of the 6th Chinese Biomedical Engineering Society

Council Member of the Biomechanics and Biorheology Committee

Committee member (Vice Chairman) of the 5th China Society of Biomechanics

 

Member of Editorial Board

 

 Editorial Board Member of “Journal of Medical Biomechanics” (Chinese), “Acta Biophysica Sinica”, “Journal of Medical Biomechanics (Chinese)” and “Acta Mechanica Sinica”  

 

近五年作为通讯作者发表的SCI论文(Recent Five-year Publications as Corresponding Author

 

(1)  Fan Z, Liu X, Du C, et al. Plaque components affect wall stress in stented human carotid artery: a numerical study[J]. Acta Mechanica Sinica, 2016: (ahead of print).

 

(2)  Hongyan Kang, Lianwen Sun, Yunfei Huang, Zhenze Wang, Ping Zhao,Yubo Fan,Xiaoyan Deng. Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats. Pflugers Arch - Eur J Physiol (2015) 467:1291–1301

 

(3)  Anqiang Sun, Zhenze Wang, Zhenmin Fan, Xiaopeng Tian, Fan Zhan, Xiaoyan Deng,Xiao Liu. Influence of proximal drug eluting stent (DES) on distal bare metal stent (BMS) in multi-stent implantation strategies in coronary arteries. Medical Engineering and Physics 37 (2015) 840–844.

 

(4)  Xiao Liu, Min Wang, Nan Zhang, Zhanming Fan, Yubo Fan,Xiaoyan Deng. Effects of endothelium, stent design and deployment on the nitric oxide transport in stented artery: a potential role in stent restenosis and thrombosis. Med Biol Eng Comput (2015) 53:427–439

 

(5)  Xue Yan, Liu Xiao, Sun Anqiang, Zhang Peng, Fan Yubo, Deng Xiaoyan . Hemodynamic Performance of a New Punched Stent Strut: A Numerical Study[J]. Artificial Organs, 2015.

 

(6)  Sun Anqiang , Tian Xiaopeng, Zhang Nan, Xu Zaipin, Deng Xiaoyan, Liu Ming and Liu Xiao. Does lower limb exercise worsen renal artery hemodynamics in patients with abdominal aortic aneurysm?[J]. PloS one, 2015, 10(5).

 

(7)  Zhang P, Liu X, Sun AQ, Deng XY. Hemodynamic insight into overlapping bare-metal stents strategy in the treatment of aortic aneurysm. J Biomech. 2015, 48:2041-2046.

 

(8)  Liu X, Sun AQ, Fan YB, Deng XY. Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications. Ann Biomed Eng. 43(4):3-15 (2015)

 

(9)  Sun AQ, Wang ZZ, Zhan F, Xu ZP, Deng XY. A New Way to Optimize Drug Release Rate of Drug Eluting Stent (Des). Journal of Mechanics in Medicine and Biology. 2015: 1550064.


(10)  Chen ZS, Zhan, F, Ding J, Zhang XW, Deng XY. A new stent with streamlined cross-section can suppress monocyte cell adhesion in the flow disturbance zones of the endovascular stent. Comput Methods Biomech Biomed Engin. (2014,online)


(11)  Wang ZZ, Liu X, Kang HY, Sun AQ, Fan YB, Deng XY. Effect of shear stress on water and LDL transport through cultured endothelial cellmonolayers Enhanced accumulation of LDLs within the venous graft wall induced by elevated filtration rate mayaccount for its accelerated atherogenesis. Atherosclerosis 236(1):198-206 (2014)


(12)  Zhang P, Sun AQ, Zhan F, Luan J, Deng XY. Hemodynamic study of overlapping bare-metal stents intervention to aortic aneurysm. J Biomech. 47(14):3524-30 (2014)


(13)  Liu X, Wang ZZ, Zhao P, Fan ZM, Sun AQ, Zhan F, Fan YB, Deng XY. Nitric oxide transport in normal human thoracic aorta: effects of hemodynamics and nitricoxide scavengers. PLoS One 9(11):e112395(2014)

 

(14)  Kang HY, Sun LW, Huang YF, Wang ZZ, Zhao P, Fan YB, Deng XY. Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats. Pflugers Arch. DOI: 10.1007/s00424-014-1568-1 (2014)


(15)  Kang HY, Liu ML, Fan YB, Deng XY. A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation. Astrobiology 13(7):626-36 (2013)

(16)  Liu X, Fan YB, Sun AQ, Deng XY. Numerical simulation of nucleotide transport in the human thoracic aorta. J Biomech. 46(4):819-27 (2013)


(17)  Fan ZM, Sun AQ, Liu X, Fan YB, Zhao P, Deng XY.The accelerated atherogenesis of venous grafts might be attributed to aggravated concentration polarization of low density lipoproteins: A numerical study. J Biomech 46(14):2388-93 (2013)


(18)  Kang HY, Fan YB, Sun AQ, Jia XL, Deng XY. Simulated Microgravity Exposure Modulates the Phenotype of Cultured Vascular Smooth Muscle Cells. Cell Biochem Biophys. 66(1):121-30 (2013)


(19)  Sun AQ, Fan YB, Deng XY. Intentionally induced swirling flow may improve the hemodynamic performance of coronary bifurcation stenting. Catheterization and Cardiovascular Interventions 79:371–377 (2012)

 

(20)  Ding ZF, Liu SJ, Yang B, Fan YB, Deng XY. Effect of oxidized low-density lipoprotein concentration polarization on human smooth muscle cells' proliferation, cycle, apoptosis and oxidized low-density lipoprotein uptake. Journal of the Royal Society Interface. 2012 Jun; 9(71):1233-40.


(21)  Zhan F, Fan YB, Deng XY. Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end- to- end anostomoses. Acta Mechanica Sinica 2011;27  (5):833-839.


(22)  Liu X, Fan YB, Deng XY, Zhan F. Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta. Journal of Biomechanics 2011;44:1123-1131.


(23)  Liu X, Fan YB, Deng XY. Effect of the endothelial glycocalyx layer on arterial LDL transport under normal and high pressure. Journal of Theoretical Biology 2011;283(1):71-81.


(24)  Liu X, Fan YB, Deng XY. Mechanotransduction of Flow-Induced Shear Stress by Endothelial Glycocalyx Fibers is Torque Determined. ASAIO Journal 2011;57(6):487-94.


(25)  Chen ZS, Fan YB, Deng XY. A novel deployment design of vena cava filters might be the solution to their blockage problem. Medical Hypotheses 2011;77(6):990-2.


(26)  Chen ZS, Fan YB, Deng XY, Zhai XP. A New Way to Reduce Flow Disturbance in Endovascular Stents: A Numerical Study. Artificial Organs 2011;35(4):392-7.


(27)  Chen ZS, Fan Z, Fan YB, Deng XY. A novel way to reduce thrombus build-up in vena cava filters. Catheterization and Cardiovascular Interventions 2011;78(5):792-8.


(28)  Kang HY, Fan YB, Deng XY. Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration and NO production responses. Am J Physiol Heart Circ Physiol 2011;300(1):H76-83.


(29)  Kang HY, Fan YB, Sun AQ, Deng XY. Compositional or charge density modification of the endothelial glycocalyx accelerates flow-dependent concentration polarization of low-density lipoproteins. Experimental Biology and Medicine 2011;236(7):800-7.


(30)  Zhou J, Lin J, Zhou CH, Deng XY, Xia B. Cytotoxicity of red fluorescent protein DsRed is associated with the suppression of Bcl-xL translation. FEBS Letters 2011;585:821-827.


(31)  Zhou J, Lin J, Zhou CH, Deng XY, Xia B. An improved bimolecular fluorescence complementation (BiFC) tool based on super-folder GFP. Acta Biochimica et Biophysica Sinica 2011;43: 239–244.


(32)  Wen J, Zheng TH, Jiang WT, Deng XY, Fan YB. A comparative study of helical-type and traditional-type artery bypass grafts: numerical simulation. ASAIO Journal 2011;57(5):399-406


(33)  Liu X, Fan YB, Deng XY. Effect of spiral flow on the transport of oxygen in the aorta: a numerical study. Ann Biomed Eng 2010;38(3):917-926.


(34)  Sun AQ, Fan YB, Deng XY. Numerical comparative study on the hemodynamic performance of a new helical graft with noncircular cross section and swirl graft. Artificial  organs 2010;34(1):22-27


(35)  Sun AQ, Fan YB, Deng XY, Xu ZP. Hemodynamic performance of a sutureless anastomosis device (the Graft Connector): A numerical study. International Journal of Artificial Organs 2010;33(6):392-398


(36)  Ding ZF, Fan YB, Deng XY. Concentration polarization of oxidative modification of low-density lipoproteins: its effect on oxidative modification of low-density lipoprotein uptake and apoptosis of the endothelial cells. ASAIO  JOURNAL 2010;56(5):468-474


(37)  Ding ZF, Fan YB, Deng XY, Zhan F, Kang HY. Effect of swirling flow on the uptakes of native and oxidized LDLs in a straight segment of the rabbit thoracic aorta. Experimental Biology and Medicine 2010;235:506-513


(38)  Ding ZF, Fan YB, Deng XY, Sun AQ, Kang HY. 3,3 '-Dioctadecylindocarbocyanine-low-density lipoprotein uptake and flow patterns in the rabbit aorta-iliac bifurcation under three perfusion flow conditions. Experimental Biology and Medicine 2010;235:506-513


(39)  Zhan F, Fan YB, Deng XY, Xu ZP. The beneficial effect of swirling flow on platelet adhesion to the surface of a sudden tubular expansion tube: its potential application in end-to-end arterial anastomosis. ASAIO J 2010;56(3):172-179


(40)  Zhan F, Fan YB, Deng XY. Swirling flow created in a glass tube suppressed platelet adhesion to the surface of the tube: its implication in the design of small-caliber arterial grafts. Thrombosis Research 2010;125(5):413-418

 

 

专利:

1     孙安强, 邓小燕, 樊瑜波, 贡向辉. 一种带有偏流导引器的人造血管. 专利号:ZL2008102229630. 授权公告日:20110504

2     孙安强,邓小燕,樊瑜波. 一种血管吻合器. 专利号:ZL2009100820283. 授权公告日:20110504

3   陈增胜,邓小燕,樊瑜波. 一种腔静脉滤器. 申请号:201110113707.X. 申请日:20110504

4   陈增胜,邓小燕,樊瑜波. 一种腔静脉滤器. 申请号:201110121164.6. 申请日:20110511

5   陈增胜,邓小燕,樊瑜波. 一种能实现零角度搭桥的人造血管. 申请号:201110135993.X. 申请日:20110524

6   孙安强,邓小燕,樊瑜波. 一种左心辅助装置. 申请号:201110162363.1. 申请日:20110616

7   陈增胜,邓小燕,樊瑜波. 一种流线型截面细丝组成的螺旋支架. 申请号:201010164474.1. 申请日:20100429

8   滕晓晶,邓小燕,樊瑜波. 一种血管内支架旋流导引装置. 申请号:200810225541.9. 申请日:20081105

9   陈颖,邓小燕,樊瑜波. 旋动流式腔静脉滤器. 申请号:200810226224.9. 申请日:20081110

10  孙安强, 邓小燕, 樊瑜波, 王振泽, 占帆, 刘肖. 药物涂层支架.申请号:201210033679.5

11  孙安强, 邓小燕, 樊瑜波, 王振泽, 占帆, 刘肖. 一种药物涂层支架.申请号:201210034036.2

12  孙安强, 邓小燕, 樊瑜波, 刘肖, 占帆, 王振泽.一种覆膜支架.申请号:201210033984.4

13  邓小燕, 王振泽, 刘肖, 孙安强. 一种血管支架. 申请号:201410349942

课题组承担的课题

1      国家自然科学基金重点项目,血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究(11332003), 2014.01-2018.12

2      国家自然科学基金重点项目,动脉系统中的旋动流现象-它对血小板运动、粘附和物质(LDL)输运的影响及其在临床中的应用(10632010), 2007.1-2010.12

3      国家自然科学基金面上项目,动脉系统中脂质的浓度极化与脂质在血管内皮层中沉积的相关性研究(30670517), 2007.1-2009.12

4      国家自然科学基金面上项目,血管内皮细胞糖萼形态结构变化与动脉系统中脂质浓度极化的相关性研究(11072023), 2011.1-2013.12

5      国家自然科学基金面上项目,血管内脂质的浓度极化与血管搭桥术后静脉血管老化(加速粥样硬化)现象的相关性研究(31170904), 2012.1-2015.12

6      国家自然科学基金面上项目,动脉系统旋动流在抑制动脉粥样硬化中所起生理作用的研究(11572028), 2016.01-2019.12

7      国家自然科学基金面上项目,腹主动脉瘤修复术后发生在膨大的生物力学机理研究(11472031), 2015.01-2018.12

8      国家自然科学基金面上项目,一氧化氮在动脉中的输运规律及其与动脉粥样硬化局部性现象的相关性研究 (31570947), 2016.01-2019.12

9      国家自然科学基金青年科学基金项目,糖萼作为力感受器在模拟失重致大鼠动脉血管功能重建中的作用研究(31500763), 2016.01-2018.12

10    国家自然科学基金青年科学基金项目,流动刺激下,内皮细胞糖萼介导的力传导与内皮细胞出芽(血管新生)的相关性研究(31200703),  2013.01- 2015.12

11    国家自然科学基金青年科学基金项目,腹主动脉瘤修复引起肾动脉狭窄和肾功能异常的血流动力学研究(11102014),  2012.1-2014.12

12    国家自然科学基金海外及港澳学者合作研究基金,人体冠脉分叉处血管支架介入治疗的血流动力学研究(11228205),  2013.01-2014.12

课题组主要成员

 

副教授              

孙安强

副教授,硕导。2010年毕业于北京航空航天大学生物与医学工程学院,获生物医学工程博士学位。主要从事血流动力学、血管介入器械等方面的研究工作。以一作及通讯作者发表SCI论文10篇,以第一发明人身份申请国家发明专利6项(2项已授权)。目前主持自然科学基金面上项目一项,参与自然科学基金重点、科技部科技支撑计划课题等多项。

E-Mail:saq@buaa.edu.cn

 

 

 

讲师              

刘 肖

讲师,硕导。2012年毕业于北航生物与医学工程学院/高等工程学院,博士期间曾到英国帝国理工学院访学。目前主要从事血流动力学、心血管系统中的物质传输、内皮细胞中的力传导,血管新生等方面的研究工作。获得2013年北京市优秀博士论文,教育部学术新人,北航蓝天新秀和北航博士创新基金等,现主持国家自然科学基金等项目。

E-Mail:liuxiao@buaa.edu.cn

 

 

     讲师          

康红艳

讲师,硕导。2014年毕业于北京航空航天大学生物与医学工程学院,博士期间曾到纽约城市学院生物医学工程系The Wallace H. Coulter Laboratory for Cardiovascular Dynamics and Biomolecular Transport访学1年。目前主要从事血管细胞糖萼力传导、物质跨内膜输运、模拟失重条件下的血管重构等方面的研究工作。曾获教育部学术新人奖,博士研究生国家奖学金等,目前主持国家自然科学基金青年科学基金项目一项。

E-Mail:kanghongyan86@163.com

 

 

博士生            

范振敏

研究方向:血流动力学

主要从事动脉粥样硬化形成机制相关血流动力学研究。

E-Mail: fanzhenmin2009@163.com

 

博士生             

陈 颖

研究方向:生物力学

主要从事血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究。

E-Mail:chenying120@163.com

博士生            

刘 明

研究方向:血流动力学

主要从事血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究。

E-Mail:469564255@qq.com

 

博士生            

赵 萍

研究方向:细胞生物力学

主要从事内皮细胞糖萼的生物力学相关研究。

E-Mail:pingzhao1007@163.com

 

博士生            

张 鹏

研究方向:生物力学

从事多层金属支架叠放隔绝术治疗主动脉瘤的血流动力学机制研究。

E-Mail:zhangpengmpg@163.com

博士生            

李晓银

 

研究方向:血流动力学

主要从事血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究。

E-Mail:lxy10241028@163.com

硕士生            

田小鹏

研究方向:血流动力学

主要从事血管动脉瘤相关的生物力学研究。

E-Mail:tianzhen@be.buaa.edu.cn

硕士生        

任长辉

研究方向:细胞生物力学

主要从事内皮细胞与平滑肌细胞的生物力学研究。

E-Mail:ren_chang18hui@163.com

硕士生            

薛 燕

研究方向:血流动力学

主要从事血管支架血流动力学优化相关研究。

E-Mail:xuezhongfeiyan555@163.com

 

硕士生            

王丽冰

 

研究方向:血流动力学

主要从事旋动流相关数值模拟研究。

E-Mail:1282035616@qq.com

硕士生            

李 洁

 

研究方向:血流动力学

主要从事血管动脉瘤相关的生物力学研究。

E-Mail:942261392@qq.com

 

 

 

生活剪影  

 

   

 

 

 

 

 

 

 

 

 

 

 

 

联系方式:

地址:北京、北京航空航天大学、生物与医学工程学院,100191

电子邮件: dengxy1953@buaa.edu.cn

 

Contact Information:

Address:  School of Biological Science and Medical Engineering, Beihang UniversityXueyuan Road No.37, HaiDian District, Beijing, 100191, China

Email:   dengxy1953@buaa.edu.cn