教授
戴克胜

职称职务:教授 博士生导师
办公地点:逸夫科学馆419
联系电话:010-82338393
E-mail:kdai@buaa.edu.cn
 

    戴克胜,北京航空航天大学“蓝天学者”特聘教授,生物与医学工程学院教授,博士生导师。1988年获蚌埠医学院医学学士学位,同年留校任教;1996年获中山大学(原中山医科大学)医学硕士学位;2002年获苏州大学医学博士学位,同年赴美国University of Illinois从事研究工作(Research Associate)。2005年底至今任教北航。迄今发表学术著作80余篇,曾获全国优秀博士学位论文,Postdoctoral Fellowship Award (American Heart Association)等奖励、资助,入选教育部“新世纪优秀人才支持计划”。为中国病理生理学会微循环专业委员会委员, 中国中西医结合学会微循环专业委员会委员,Frontiers of Biology in China等杂志编委。主要研究方向:血栓与止血,细胞信号转导及凋亡调控机制,空间生理学。

 

近期代表性论文(*为通讯作者):

1. Suping Li, Quanwei Shi, Guanglei Liu, Weilin Zhang, Zhicheng Wang, Yuedan Wang, Kesheng Dai*. Mechanism of platelet functional changes and the effects of anti-platelet agents on in vivo hemostasis under different gravity conditions. Journal of Applied Physiology. 2010 Feb. 4, [Epub ahead of print, in press].

2. Suping Li, Zhicheng Wang, Yi Liao, Weilin Zhang, Quanwei Shi, Rong Yan, Changgeng Ruan, Kesheng Dai*. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. Journal of Thrombosis and Haemostasis 2010, 8: 341-50.

3.   Zhicheng Wang, Quanwei Shi, Suping Li, Juan Du, Jun Liu, Kesheng Dai*. Hyperthermia induces platelet apoptosis and glycoprotein Ibα ectodomain shedding. Platelets 2010, 21: 229-237.

4.   Zhicheng Wang, Suping Li, Quanwei Shi, Rong Yan, Guanglei Liu, Kesheng Dai*. Calmodulin antagonists induce platelet apoptosis. Thrombosis Research 2010, 125: 340-350.

5.    Zhicheng Wang, Quanwei Shi, Rong Yan, Guanglei Liu, Weilin Zhang, Kesheng Dai*. The role of calpain in the regulation of ADAM17-dependent GPIbaectodomain shedding. Archives of Biochemistry and Biophysics2010, 495: 136-143.

6.   Yanhong Yuan, Weilin Zhang, Rong Yan, Yi Liao, Lili Zhao, Changgeng Ruan, Xiaoping Du, Kesheng Dai*. Identification of a novel 14-3-3ζ binding site within the cytoplasmic domain of platelet glycoprotein Iba that plays a key role in regulating the VWF binding function of glycoprotein Ib-IX. Circulation Research 2009,105: 1177-85.

7.    Hong Cheng, Suping Li, Yanhong Yuan, Rong Yan, Changgeng Ruan, Kesheng Dai*. Shear-induced von Willebrand factor-dependent platelet glycoprotein Ibα shedding. The American Journal of Physiology-Heart and Circulatory Physiology 2009, 297: H2128-35.

8.   Rong Yan, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Kesheng Dai*. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Archives of Biochemistry and Biophysics 2009, 485: 41-48.

9.   Suping Li, Quanwei Shi, Zhicheng Wang, Rong Yan, Hong Cheng, Kesheng Dai*. Hypergravity Results in Human Platelet Hyperactivity. Journal of Physiology and Biochemistry 2009, 65: 147-156.

10. Rong Yan, Suping Li, Kesheng Dai*. The critical roles for cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology. Frontiers of Biology in China, 2009; 4: 7-14. (Review)

11. Kesheng Dai*, Yuedan Wang, Rong Yan, Quanwei Shi, Zhicheng Wang, Yanhong Yuan, Hong Cheng, Suping Li, Yubo Fan, Fengyuan Zhuang. Effects of microgravity and hypergravity on platelet function. Thrombosis and Haemostasis 2009, 101: 902-910.

12. Kesheng Dai*, Rong Yan, Suping Li, Yubo Fan, Fengyuan Zhuang, Changgeng Ruan. Prolonged inhibition of protein kinase A results in the dysfunction of platelet by GPIba shedding. Thrombosis Research 2009, 124: 101-109.

13. Kesheng Dai, Richard J. Bodnar, Michael C. Berndt, Xiaoping Du. A critical role for 14-3-3 protein in platelet adhesion and its therapeutic implications. Blood 2005, 106: 1975-1981.

14. Kesheng Dai, Huaiping Zhu, Changgeng Ruan. Construction, expression and characterization of a single chain Fv specific against platelets GP Ibα. Thrombosis Research 2003; 109: 137-144.

15. Kesheng Dai, Weiqing Gao, Changgeng Ruan. The Sma I polymorphism in the von Willebrand factor gene associated with acute ischemic stroke. Thrombosis Research 2001; 104: 389-395.