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林嘉盈 博士
卓越百人教授博导
生物与医学工程学院
北京航空航天大学
教育经历
2002/01-2004/12，美国密歇根大学安娜堡分校，生物与医学工程，博士
2000/09-2002/06，美国密歇根大学安娜堡分校，生物与医学工程，硕士
1993/09-1997/06，国立台湾大学，土木工程学系，本科
研究工作经历
2014/03-今，北京航空航天大学，生物与医学工程学院，卓越百人教授博导
2011/11-2014/02，助理教授，神经外科、矫形外科和生物医学工程，美国密歇根大学
2007/09-2011/12，助理教授（研究系列），神经外科和生物医学工程，美国密歇根大学
2004/12-2007/08，研究讲师，神经外科和生物医学工程，美国密歇根大学
学术背景
美国密西根大学生物医学工程博士(2004年)，北京航空航天大学生物与医学工程学院教授。曾任美国密西根大学医学院神经外科学系、骨外科学系及医学工程系助理教授，获得美国生物医学材料学会杰出年轻学者科研发展奖及世界先进脊柱医学技术学会Whitecloud基础医学研究奖候选人。现为美国生物医学材料学会、国际干细胞研究学会、美国骨科医学研究会、世界华人生物医学工程学会及美国肿瘤研究学会会员，并任两个著名期刊Journal of Stem Cell Research & Therapy及JSM Neurosurgery & Spine编委，被邀为十多个重大期刊如Tissue Engineering及Cell Proliferation审稿。长期从事组织工程与再生医学、微创组织修复开发及抑制骨肿瘤分化疗法等的研究；曾承担多项NIH课题；著作含SCI论文、书目章节及国际会议摘要等60余篇。
主要研究领域
组织工程与再生医学、微创组织修复开发及抑制骨肿瘤分化疗法
近三年主要论著
1、期刊论文：
[1] Khoi D. Than, Shayan U. Rahman, Lin Wang, Adam Khan, Kwaku A. Kyere, Tracey T. Than, Yoshinari Miyata, Yoon-Shin Park, Frank La Marca, Hyungjin M. Kim, Huina Zhang, Paul Park, Chia-Ying Lin* : Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. The Spine Journal, in press
[2] Lin Wang, Paul Park, Frank La Marca, Khoi Than, Shayan Rahman, Chia-Ying Lin*: Bone formation induced by BMP-2 in human osteosarcoma cells. Int. J. Oncology 43(4): 1095-102, 2013.
[3] Heesuk Kang, Scott J. Hollister, Frank La Marca, Paul Park, Chia-Ying Lin* : Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering. J Biomech Eng 135(10): 101013-8, 2013.
[4] Wang L, Park P, Zhang H, La Marca F, Claeson A, Than K, Rahman S, Lin CY*: BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. Int. J. Cancer 131(8): 1941-1950, 2012. PM22275155
[5] Wang Lin, Park Paul, La Marca Frank,Than Khoi, Rahman Shayan, Lin Chia-Ying*: Advancements in suppression of osteosarcoma tumorigenicity: a prospective look. Journal of Cancer Therapy 3(4): 327-30, 2012.
[6] Lin CY*: Commentary. Neurosurgery 71(1): 125, 2012. PM22893912
[7] Than KD, Rahman SU, Vanaman MJ, Wang AC, Lin CY, Zhang H, La Marca F, Park P*: Bone morphogenetic proteins and degenerative disk disease. Neurosurgery 70(4): 996-1002, 2012. PM22426045
[8] Park YS, David AE, Park KM, Lin CY, Than KD, Lee K, Park JB, Jo I, Park KD, Yang VC*: Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells. The AAPS Journal 15(2): 367-76, 2012. PM23250670
[9] Park JB, Zhang H, Lin CY, Chung CP, Byun Y, Park YS, Yang VC*: Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors α. The Journal of Surgical Research 174(2): 278-83, 2012. PM21324392
[10] Wang L, Rahman S, Lin CY, Valdivia J, Than K, La Marca F, Park P*: A novel murine model of human renal cell carcinoma spinal metastasis. J Clin Neurosci 19(6): 881-883, 2012. PM22516545
[11] Wang L, Park P, Zhang H, La Marca F, Claeson A, Valdivia J, Lin CY*: BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer Biol. Ther. 11(5): 457-463, 2011. PM21178508
[12] Wang L, Park P, Zhang H, La Marca F, Lin CY*: Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. Int. J. Cancer 128(2): 294-303, 2011. PM20309879
[13] Zhang H, Yang S, Wang L, Park P, La Marca F, Hollister SJ, Lin CY*: Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation. J Neurosurg Spine 15(4): 404-413, 2011. PM21721872
2、会议论文：
[1] Than KD, Rahman SU, Wang L, Kyere KA, Than TT, Khan A, La Marca F, Park P, Zhang H, and Lin CY*: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease (Whitecloud Basic Science Award Nominee), The 19th International Meeting on Advanced Spine Techniques, Istanbul, Turkey, 2012.
[2] Wang L, Park P, Than KD, Rahman SU, La Marca F, and Lin CY*: BMP-2 inhibits tumor growth of human renal cell carcinoma by induction of bone formation, The 2012 AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting, Orlando, FL, 2012.
[3] Than KD, Rahman SU, Wang L, Khan A, Kyere KA, La Marca F, Zhang H, Park P, and Lin CY*: Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease, The 2012 Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 2012.
[4] Wang, L., Park, P., Zhang, H., La Marca, F. and Lin, C.Y.*: BMP-2 Inhibits the Tumorigenicity of Human Osteosarcoma Tumor-Initiating Cells, 101th Annual Meeting American Association of Cancer Research, Washington, D.C., 2011.
[5] Wang, L., Park, P., Zhang, H., La Marca, F. and Lin, C.Y.*: Characterization of Renal Tumor-Initiating Cells in Human Renal Carcinoma Cell Lines, 102nd Annual Meeting American Association of Cancer Research, Orlando, FL, 2011.
[6] Rahman S, Zhang H, Than K, La Marca F, and Lin CY*: Developing intervertebral disc degeneration in rat caudal spine using needle puncture with and without rotational injury, 18th International Meeting on Advanced Spine Techniques, Copenhagen, Denmark, 2011.
[7] Zhang, H., Yang, S., Wang, L., Park, P., La Marca, F., Hollister, S.J., and Lin, C.Y.*: Time Course Investigation of Intervertebral Disc Degeneration Produced by Needle Stab Injury of the Rate Caudal Spine, 57th Meeting Orthopaedic Research Society, Long Beach, CA, 2011.
[8] Park YS, David AE, Lin CY, Rahman S, Zhang H, Than K, Wang L, Park JB, Park KM, Park KD, Lee SJ, and Yang VC.*: Controlled-release of simvastatin from hydrogels and its triggering of bone formation in MC3T3-E1 cells, The American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Washington D.C., 2011.
3、专著：
[1] Lin CY, Tobia W, La Marca, F, and Hollister SJ: Structural and Mechanical Evaluations of a Topology Optimized Titanium Interbody Fusion Cage Fabricated by Selective Laser Melting Process. Computer Aided Biomanufacturing, R. Narayan and P. Calver Wiley-VCH, 2011.
4、奖励：
[1] Lin CY, 2012 Whitecloud Basic Science Award Nominee, International Advanced Spine Techniques (2012年世界先进脊柱医学技术学会提名年度Whitecloud基础医学研究奖候选人), 2012
5、专利：
[1] Lin CY, Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration, Co-inventor, 2012.9, 美国, US 8,275,594
[2] Lin CY, Biodegradable/bioresorbable tissue augmentation/reconstruction device, Co-inventor, 2011.7, 美国, US 7,979,150
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