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博士后
陈晓芳
 

陈晓芳 博士 副教授;

北京航空航天大学生物与医学工程学院;

北京航空航天大学“卓越百人”

 

Xiaofang Chen, Ph.D.

Associate Professor, School of Biological Science and Medical Engineering, Beihang University

Tel010-82339861             Email: xfchen@buaa.edu.cn

 

主要教育、科研简历:

1997-2001清华大学精密仪器与机械学系,学士

2001-2004清华大学生命科学与技术系,硕士

2004-2009美国加州大学欧文分校,生物医学工程系,博士。

2010-2011美国加州大学伯克利分校,生物工程系,博士后。

2013起,北京航空航天大学生物与医学工程学院副教授,北航“卓越百人”。 

 

Education

1997-2001: B.E. Department of precision Instruments and Mechanology, Tsinghua University

2001-2004: M.S. Life Science and Biotechnology, Tsinghua University

2004-2009: Ph.D. Biomedical Engineering, University of California, Irvine

Professional Experience

2010-2011: Post doctoral scholar, Department of Bioengineering, University of California, Berkeley

2013 Associate Professor, School of Biological Science and Medical Engineering, Beihang University

 

主要研究方向:

    我的研究方向是组织工程,即体外构建人造组织。目前对于许多人类重大疾病比如心肌梗死、肝硬化等还没有行之有效的治疗手段,对于这些疾病发病机理的研究并不透彻。人造组织有望实现人体组织的部分或全部生理功能,比二维培养的细胞更能反映体内组织的真实状况,可以用来研究疾病的发病机理,也可以用来进行药物筛选。最终将有望替代患病组织,达到治疗疾病的目的。我主要进行以下两个方面的研究

    1. 人造组织血管化:血管网向组织细胞运输血液,是组织存活必不可少的部分。我们将在体外构建三维血管网络,利用微流控等工程手段控制血管生长,研究力学环境对血管功能的影响,并诱导血管功能成熟;在此基础上构建血管化的人造组织。

    2. 利用基因编辑技术获取组织细胞(细胞重编程):细胞是实现组织功能的基本单元,而许多组织细胞比如人心肌细胞,肝脏细胞很难进行体外培养和增殖,如何获取大量的具有生物功能的组织细胞是目前组织工程的另一个难题。我将利用基因工程技术,对成纤维细胞或间充质干细胞进行改造,以改变其生理功能和命运。

Research Interests

1.  Vascularization of engineered tissue

2.  Gene targeting, cell reprogramming

 

近期主要论著(Recent Publications Selected:

1.        Deng, Y., Y. Sun, X. Chen, P. Zhu, and S. Wei. Biomimetic Synthesis of Bone-like Apatite inPolysaccharide-gelatin Hybrid Hydrogel by Single-directional Diffusion Process. Materials Science and Engineering C, 33(5): 2905-2913, 2013

2.       Chen, X., M.A. Kapil, A.J. Hughes, and A.E. Herr. A single-microchannel, multi-step assay reports protein size and immunoaffinity. Analytical Chemistry, 83(17): 6573-6579, 2011

3.       Chen, X., A. S. Aledia, S.A. Popson, L. Him, C.C.W. Hughes, and S.C. George. Rapid anastomosis of endothelial precursor cell-derived vessels with host vasculature is promoted by a high density of co-transplanted fibroblasts. Tissue Engineering, Part A, 16(2): 585-94, 2010

4.       Chen, X., A. S. Aledia, C.M. Ghajar, C.K. Griffith, A.J. Putnam, C.C.W. Hughes, and S.C. George. Prevascularization of a fibrin based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Engineering, Part A, 15(6): 1363-1371, 2009. (Editor’s Pick, ranked in the top 10% in this field)

5.       Ghajar, C.M., X. Chen, J.W. Harris, V. Suresh, C.C.W. Hughes, N.L. Jeon, A.J. Putnam, and S.C. George. The effect of matrix density on 3-D capillary morphogenesis. Biophysical Journal, 94: 1930-1941, 2008

6.       Shen, K., X. Chen, M. Guo, and J. Cheng. A novel thermal component and temperature control in micro PCR using flexible printed circuit technology. Sensors and Actuators B, 105: 251-258, 2005.

7.       Chen, X., K. Shen, P. Liu, G. Liu, M. Guo, J. Cheng, and Y. Zhou. Silica-based solid phase extraction of DNA on a microchip. Tsinghua Science and Technology, 9: 379-383, 2004

8.       Liu, C., M. Guo, X. Chen, and J. Cheng. Low voltage driven miniaturized pump with high backpressure. SPIE, 4982: 344-355, 2003

国际会议发言:

1.       Chen, X., A.S. Aledia, S.A. Popson, L. Him, C.C. Hughes, and S.C. George. Engineering functional 3-dimensional vessel networks. Biomedical Engineering Society annual fall meeting, Oct. 2009, Pittsburg

2.       Chen, X., A.S. Aledia, S.A. Popson, L. Him, C.C. Hughes, and S.C. George. Engineering functional 3-dimensional vessel networks. Biomedical Engineering Society annual fall meeting, Oct. 2009, Pittsburg

获得科研基金情况:

1 国家自然科学基金青年项目,2014-2016

2 “卓越百人”条件建设经费,2013年

联系方式:

通讯地址:北京市海淀区学院路37号,北京航空航天大学,生物与医学工程学院

邮编:100191 
电话:010-82339861       电子邮件:xfchen@buaa.edu.cn

 

Contact Information:

Address: School of Biological Science and Medical Engineering, Beihang University

XueYuan Road No.37, HaiDian District, Beijing, 100191, China

Tel010-82339861           Email:xfchen@buaa.edu.cn