讲师
邓小燕
 

邓小燕 博士

北京航空航天大学 生物与医学工程学院 教授
北航首届十佳“教书育人”优秀研究生导师
Xiaoyan Deng, Ph.D. & Professor
School of Biological Science and Medical Engineering, Beihang University, Beijing
Email:
dengxy1953@buaa.edu.cn


课题组承担多项血流动力学、细胞生物力学、人工器官和血管植/介入器械相关课题,欢迎生物医学工程、生物、力学、机械等相关专业本科生报考研究生。

主要教育、科研简历

主要教育经历

 

1991  加拿大麦吉尔大学 (McGill University),化学工程系及临床研究所,生物医学工

      程专业博士

1982   成都科技大学,工程力学系,生物力学专业硕士  

1975   武汉华中理工大学,火电站专业本科专业

 

主要工作经历

 

2008至今  北京航空航天大学生物与医学工程学院          教授,博导

20052008  北京航空航天大学生物工程系                  教授,博导,

20022004  重庆大学生物工程学院                        教授,博导,院长

20002002  大连理工大学工程力学系                      教授,博导

19952000  加拿大魁北克拉瓦尔大学生物材料研究所        研究员

            加拿大魁北克拉瓦尔大学医学院外科系          科研教授

19911995  加拿大魁北克拉瓦尔大学生物材料研究所        博士后

19831985  成都科技大学 (现四川大学)  工程力学系     助教

19781980  四川省环境保护研究所                        助理工程师

19751978  西南核反应堆研究设计院(二机部第一设计院)  反应堆操纵员

 

Education

 

10/1991    Ph.D., Biomedical Engineering, Department of Chemical Engineering,

                 McGill Medical Clinic, McGill UniversityMontrealCanada

12/1982    M.S., Biomechanics, Department of Engineering Mechanics, Chengdu

                 University of Science and Technology, ChengduChina

10/1975    Graduation, Power Station, Huazhong University of Science and

                 Technology, WuhanChina

                 

Professional Experience

 

2005-Present   Professor, School of Biological Science and Medical Engineering,

                         Beihang UniversityChina

2002-2004       Professor and Dean, College of Bioengineering,

                         Chongqing UniversityChongqing, China

2000-2002       Professor, Dalian University of TechnologyDalian, China

1995-2000       Senior Researcher and Research Professor (Professeur Asscié),

                         Department of Surgery and Quebec Biomaterials Institute,

                         Laval UniversityCanada                    

1991-1995       Postdoctoral Fellow, Quebec Biomaterials Institute,

                         Laval UniversityCanada

1983-1985       Assistant Professor, Department of Engineering Mechanics,

                         Chengdu University of Science and Technology, Chengdu, China

1978-1980       Engineer, Sichuan Provincial Environment Protection Research

                         Institute, Chengdu, China

1975-1978       Nuclear Reactor Operator, South-West Nuclear Reactor Research

                         Center of ChinaChina

 

主要研究方向

 

1.血流动力学

2.心血管介入器械与人工器官

3.细胞生物力学与力生物学

 

Research Interests

 

1.Hemodynamics

2.Cardiovascular Implants and Devices

3.Cell Biomechanics and Mechanobiology

 

主要社会兼职

 

中国生物医学工程学会(第六届)                    理事

中国生物物理学会生物力学及生物流变学专业委员会   委员

生物力学专业委员会(第五届)                      副主任

生物力学专业委员会(第六届)                      委员

《生物物理学报》                                编委

《医用生物力学》                                编委

《生物医学工程学杂志》                          编委

《力学学报》(英文版)                          编委

 

Memberships of Professional Societies

 

Council Member of the 6th Chinese Biomedical Engineering Society

Council Member of the Biomechanics and Biorheology Committee

Committee member (Vice Chairman) of the 5th China Society of Biomechanics

 

Member of Editorial Board

 

Editorial Board Member of “Journal of Medical Biomechanics” (Chinese), “Acta Biophysica Sinica”, “Journal of Medical Biomechanics (Chinese)” and “Acta Mechanica Sinica”  

 

 

近期作为通讯作者发表的主要论文(Recent Publications as Corresponding Author)

1). Zhang P, Sun AQ*, Zhan F, Luan JY, Deng XY*. Hemodynamic study of overlapping bare-metal stents intervention to aortic aneurysm[J]. Journal of Biomechanics, DOI:10.1016/j.jbiomech.2014.08.025

2). Liu X, Sun AQ, Fan YB, Deng XY*. Physiological Significance of Helical Flow in the Arterial System and its Potential Clinical Applications[J]. Annals of biomedical engineering, 2014: 1-13.

3). Wang ZZ, Liu X*, Kang HY, Sun AQ, Fan YB, Deng XY*. Enhanced accumulation of LDLs within the venous graft wall induced by elevated filtration rate may account for its accelerated atherogenesis[J]. Atherosclerosis, 2014; 236(1):198-206

4). Kang HY, Sun LW, Huang YF, Wang ZZ, Zhao P, Fan YB, Deng XY*. Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats[J]. Pflügers Archiv-European Journal of Physiology, 2014: 1-11.

5). Zhan F, Chen ZS, Deng XY*. Swirling flow can suppress monocytes adhesion in end-to-end arterial anastomosis[J]. Journal of Mechanics in Medicine and Biology, 2014, 14(05).

6). Kang HY, Liu ML, Fan YB *, Deng XY*.A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation. Astrobiology 2013; 13(7):626-36

7). Ding ZF, Liu, S., Sun, C., Chen ZS, Fan YB, Deng XY*, Wang X., and Mehta, J.L. Concentration polarization of ox-LDL activates autophagy and apoptosis via regulating LOX-1expression. Sci Rep 2013;3, 2091.

8). Fan ZM, Sun AQ, Liu X, Fan YB, Zhao P, Deng XY*, The accelerated atherogenesis of venous grafts might be attributed to aggravated concentration polarization of low density lipoproteins: A numerical study[J]. Journal of biomechanics, 2013, 46(14): 2388-2393.

9). Liu X, Fan YB, Sun AQ, Deng XY*. Numerical simulation of nucleotide transport in the human thoracic aorta. J Biomech. 2013;46(4):819-27.

10). Kang HY, Fan YB, Sun AQ, Jia XL, Deng XY*. Simulated Microgravity Exposure Modulates the Phenotype of Cultured Vascular Smooth Muscle Cells. Cell Biochem Biophys. 2013;66(1):121-30

11). Sun AQ, Fan YB, Deng XY*. Intentionally induced swirling flow may improve the hemodynamic performance of coronary bifurcation stenting. Catheterization and Cardiovascular Interventions 79:371–377 (2012)

12). Ding ZF, Liu SJ, Yang B, Fan YB, Deng XY*. Effect of oxidized low-density lipoprotein concentration polarization on human smooth muscle cells' proliferation, cycle, apoptosis and oxidized low-density lipoprotein uptake. Journal of the Royal Society Interface 2012, 9(71): 1233-1240.

13). Liu X, Fan Y, Xu X Y, Deng XY*. Nitric oxide transport in an axisymmetric stenosis[J]. Journal of The Royal Society Interface, 2012, 9(75): 2468-2478.

14). Wang ZZ, Sun AQ, Fan YB, Deng XY*. Comparative study of Newtonian and non-Newtonian simulations of drug transport in a model drug-eluting stent[J]. Biorheology, 2012, 49(4): 249-259.

15). Chen ZS, Zhang XW, Deng XY*. A new design of the retrievable vena cava filter[J]. Medical hypotheses, 2012, 79(5): 635-636.

16). Zhan F, Fan YB, Deng XY*. Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end- to- end anostomoses. Acta Mechanica Sinica 2011;27 (5):833-839.

17). Liu X, Fan YB, Deng XY*, Zhan F. Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta. Journal of Biomechanics 2011;44:1123-1131.

18). Liu X, Fan YB, Deng XY*. Effect of the endothelial glycocalyx layer on arterial LDL transport under normal and high pressure. Journal of Theoretical Biology 2011;283(1):71-81.

19). Liu X, Fan YB, Deng XY*. Mechanotransduction of Flow-Induced Shear Stress by Endothelial Glycocalyx Fibers is Torque Determined. ASAIO Journal 2011;57(6):487-94.

20). Chen ZS, Fan YB, Deng XY*. A novel deployment design of vena cava filters might be the solution to their blockage problem. Medical Hypotheses 2011;77(6):990-2.

21). Chen ZS, Fan YB, Deng XY*, Zhai XP. A New Way to Reduce Flow Disturbance in Endovascular Stents: A Numerical Study. Artificial Organs 2011;35(4):392-7.

22). Chen ZS, Fan Z, Fan YB, Deng XY*. A novel way to reduce thrombus build-up in vena cava filters. Catheterization and Cardiovascular Interventions 2011;78(5):792-8.

23). Kang HY, Fan YB, Deng XY*. Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration and NO production responses. Am J Physiol Heart Circ Physiol 2011;300(1):H76-83.

24). Kang HY, Fan YB, Sun AQ, Deng XY*. Compositional or charge density modification of the endothelial glycocalyx accelerates flow-dependent concentration polarization of low-density lipoproteins. Experimental Biology and Medicine 2011;236(7):800-7.

25). Zhou J, Lin J, Zhou CH, Deng XY*, Xia B. Cytotoxicity of red fluorescent protein DsRed is associated with the suppression of Bcl-xL translation. FEBS Letters 2011;585:821-827.

26). Zhou J, Lin J, Zhou CH, Deng XY*, Xia B. An improved bimolecular fluorescence complementation (BiFC) tool based on super-folder GFP. Acta Biochimica et Biophysica Sinica 2011;43: 239–244.

27). Wen J, Zheng TH, Jiang WT, Deng XY*, Fan YB. A comparative study of helical-type and traditional-type artery bypass grafts: numerical simulation. ASAIO Journal 2011;57(5):399-406

28). Liu X, Fan YB, Deng XY*. Effect of spiral flow on the transport of oxygen in the aorta: a numerical study. Ann Biomed Eng 2010;38(3):917-926.

29). Sun AQ, Fan YB, Deng XY*. Numerical comparative study on the hemodynamic performance of a new helical graft with noncircular cross section and swirl graft. Artificial  organs 2010;34(1):22-27

30). Sun AQ, Fan YB, Deng XY*, Xu ZP. Hemodynamic performance of a sutureless anastomosis device (the Graft Connector): A numerical study. International Journal of Artificial Organs 2010;33(6):392-398

31). Ding ZF, Fan YB, Deng XY*. Concentration polarization of oxidative modification of low-density lipoproteins: its effect on oxidative modification of low-density lipoprotein uptake and apoptosis of the endothelial cells. ASAIO  JOURNAL 2010;56(5):468-474

32). Ding ZF, Fan YB, Deng XY*, Zhan F, Kang HY. Effect of swirling flow on the uptakes of native and oxidized LDLs in a straight segment of the rabbit thoracic aorta. Experimental Biology and Medicine 2010;235:506-513

33). Ding ZF, Fan YB, Deng XY,* Sun AQ, Kang HY. 3,3 '-Dioctadecylindocarbocyanine-low-density lipoprotein uptake and flow patterns in the rabbit aorta-iliac bifurcation under three perfusion flow conditions. Experimental Biology and Medicine 2010;235:506-513

34). Zhan F, Fan YB, Deng XY*, Xu ZP. The beneficial effect of swirling flow on platelet adhesion to the surface of a sudden tubular expansion tube: its potential application in end-to-end arterial anastomosis. ASAIO J 2010;56(3):172-179

35). Zhan F, Fan YB, Deng XY*. Swirling flow created in a glass tube suppressed platelet adhesion to the surface of the tube: its implication in the design of small-caliber arterial grafts. Thrombosis Research 2010;125(5):413-418

36). Sun AQ, Fan YB, Deng XY*. Numerical investigation of blood flow in the distal end of an axis-deviated arterial bypass model. Biorheology 2009;46:83–92.

37). Liu X, Pu F, Fan YB, Deng XY*. A numerical study on the flow of blood and the transport of LDL in the human aorta: the physiological significance of the helical flow in the aortic arch. Am J Physiol Heart Circ Physiol 2009;297: H163-H170.

38). Zheng TH, Fan YB, Xiong Y, Jiang WT, Deng XY. Hemodynamic performance study on small diameter helical grafts. ASAIO Journal 2009;55:192-199.

39). Ding ZF, Fan YB, Deng XY*. Effect of LDL concentration polarization on the uptake of LDL by human endothelial cells and smooth muscle cells co-cultured. Acta Biochim Biophys Sinica 2009;41:146–153.

40). Fan YB, Jiang WT, Zou YW, Li JC, Chen JK, Deng XY. Numerical simulation of pulsatile non-Newtonian flow in the carotid artery bifurcation. Acta Mech Sin 2009;25:249–255.

41). Ding ZF, Fan YB, Deng XY*. Water filtration rate and infiltration/accumulation of low density lipoproteins in 3 different modes of endothelial/smooth muscle cell co-cultures. Science in China(Series C) 2009;52:1023-1029.

42). Chen ZS, Fan YB, Deng XY*, Xu ZP. Swirling flow can suppress flow disturbances in endovascular stents: a numerical study. ASAIO Journal 2009;55:543-549.

专利:

1.   孙安强,邓小燕樊瑜波,贡向辉一种带有偏流导引器的人造血管专利号:ZL2008102229630. 授权公告日:20110504

2.  安强,邓小燕,樊瑜波一种血管吻合器专利号ZL2009100820283. 授权公告日:20110504

3.  陈增胜,邓小燕,樊瑜波一种腔静脉滤器申请号:201110113707.X. 申请日:20110504

4.  陈增胜,邓小燕,樊瑜波一种腔静脉滤器申请号:201110121164.6. 申请日:20110511

5.  陈增胜,邓小燕,樊瑜波一种能实现零角度搭桥的人造血管申请号:201110135993.X. 申请日:20110524

6.  孙安强,邓小燕,樊瑜波一种左心辅助装置申请号:201110162363.1. 申请日20110616

7.  陈增胜,邓小燕,樊瑜波一种流线型截面细丝组成的螺旋支架申请号:201010164474.1. 申请日:20100429

8.  滕晓晶,邓小燕,樊瑜波一种血管内支架旋流导引装置申请号:200810225541.9.申请日:20081105

9.  陈颖,邓小燕,樊瑜波旋动流式腔静脉滤器申请号:200810226224.9. 申请日:20081110

10.孙安强邓小燕樊瑜波王振泽占帆刘肖药物涂层支架.申请号:201210033679.5

11.孙安强邓小燕樊瑜波王振泽占帆刘肖一种药物涂层支架.申请号:201210034036.2

12.孙安强邓小燕樊瑜波刘肖占帆王振泽.一种覆膜支架.申请号:201210033984.4

课题组近期承担的课题

1国家自然科学基金重点项目,血管支架植入后力学环境变化影响血管支架内再狭窄和晚期血栓形成的机制研究(11332003),2014.01-2018.12

2、国家自然科学基金,血管内脂质的浓度极化与血管搭桥术后静脉血管老化(加速粥样硬化)现象的相关性研究(31170904),2012.1-2015.12

3、国家自然科学基金青年基金,腹主动脉瘤修复引起肾动脉狭窄和肾功能异常的血流动力学研究(11102014),2012.1-2014.12

4、国家自然科学基金,血管内皮细胞糖萼形态结构变化与动脉系统中脂质浓度极化的相关性研究(11072023),2011.1-2013.12

5、国家自然科学基金重点项目,动脉系统中的旋动流现象-它对血小板运动、粘附和物质(LDL)输运的影响及其在临床中的应用,批准号:10632010,2007.1-2010.12

6、国家自然科学基金,动脉系统中脂质的浓度极化与脂质在血管内皮层中沉积的相关性研究(30670517),2007.1-2009.12

 

课题组主要成员

 

讲师              

孙安强

讲师,硕士生导师。2010年毕业于北京航空航天大学生物与医学工程学院,获生物医学工程博士学位。主要从事血流动力学、血管介入器械等方面的研究工作。以第一作者身份在血流动力学、人工器官领域国际重要期刊发表SCI论文4篇,以第一发明人身份申请国家发明专利6项(2项已授权)。目前主持国家自然科学基金青年基金一项。

E-Mail:saq@buaa.edu.cn

 

 

 

讲师                

刘 肖

讲师,硕导。2012年毕业于北航生物与医学工程学院/高等工程学院,博士期间曾到英国帝国理工学院访学。目前主要从事血流动力学、心血管系统中的物质传输、内皮细胞中的力传导,血管新生等方面的研究工作。获得2013年北京市优秀博士论文,教育部学术新人,北航蓝天新秀和北航博士创新基金等,现主持国家自然科学基金等项目。

E-Mail:liuxiao@buaa.edu.cn

 

 

     博士生              

康红艳

研究方向:细胞生物力学

主要从事内皮/平滑肌细胞糖萼的生物力学研究。

E-Mail:kanghongyan86@163.com

 

博士生              

王振泽

研究方向:血流动力学

主要从事血流动力学仿真、动脉粥样硬化形成机制研究。

E-Mail:wangzhenze@be.buaa.edu.cn

 

博士生             

范振敏

研究方向:血流动力学

主要从事动脉粥样硬化形成机制相关血流动力学研究。

E-Mail: fanzhenmin2009@163.com

博士生             

刘 明

研究方向:血流动力学

主要从事血管支架内再狭窄生物力学研究。

E-Mail:469564255@qq.com

博士生             

赵 萍

研究方向:细胞生物力学

主要从事内皮细胞糖萼的生物力学相关研究。

E-Mail:pingzhao1007@163.com

 

博士生             

张 鹏

研究方向:生物力学

主要从事主动脉瘤生物力学计算机仿真研究。

E-Mail:zhangpengmpg@163.com

硕士生             

任长辉

研究方向:细胞生物力学

主要从事内皮细胞与平滑肌细胞的生物力学研究。

E-Mail:ren_chang18hui@163.com

硕士生             

薛 燕

研究方向:血流动力学

主要从事血管支架血流动力学优化相关研究。

E-mail:xuezhongfeiyan555@163.com

硕士生             

田小鹏

研究方向:血流动力学

主要从事血管动脉瘤相关的生物力学研究。

E-Mail:tianzhen@be.buaa.edu.cn

硕士生             

王丽冰

研究方向:生物力学与力生物学

主要从事内皮细胞的生物力学研究。

E-Mail:1282035616@qq.com

 

生活剪影  

 

   

 

 

 

 

 

 

 

 

 

 

 

 

 

 

联系方式:

 

地址:北京、北京航空航天大学、生物与医学工程学院,100191

电子邮件 dengxy1953@buaa.edu.cn

 

Contact Information:

 

Address:  School of Biological Science and Medical Engineering, Beihang UniversityXueyuan Road No.37, HaiDian District, Beijing, 100191, China

Email:   dengxy1953@buaa.edu.cn