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贾潇凌，副教授，博士生导师。主持国家自然科学基金面上项目4项，教育部青年教师基金1项，山西省自然科学青年基金1项。作为项目组骨干成员参与国家重点研发计划、国家自然科学基金创新研究群体项目等多项。以第一作者、通讯作者在国际学术刊物Biomaterials, Acta biomaterialia, Mater Sci Eng C Mater Biol Appl, Pflugers Arch, J Cell Physiol, Cell Prolif等发表多篇学术论文。
研究方向
1 血管组织工程
2 离子通道在物理因素调控细胞生理病理功能中的作用机制
教育与工作经历
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1988.9 - 1992.7 |
山西大学生物系 |
生物专业、学士 |
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1992.9 - 1995.7 |
山西大学生物系 |
动物专业、硕士 |
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1995.9 - 2003.3 |
中国辐射防护研究院 |
助理研究员 |
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2003.4 - 2007.7 |
中国科学院力学研究所 |
生物力学、博士 |
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2007.9 至今 |
北京航空航天大学
生物与医学工程学院 |
讲师、副教授 |
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2002.12 - 2003.3 |
香港中文大学生物医学学院 |
访问学者 |
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2019.7 - 2020.7 |
英国利兹大学生物医学学院 |
访问学者 |
主要社会兼职
中国生物医学工程学会 会员
中国神经科学学会 会员
Frontiers in Pharmacology （Ion channels） Associate editor (副主编)
主要教学获奖
北航第十五届“我爱我师”十佳教师
主持科研项目
1. Piezo1与BKCa或IKCa在牵张调控血管平滑肌细胞功能中的协同作用及机制，国家自然科学基金面上项目，2023.01-2026.12，55万。
2. Caveolae对TRPC1-SOCE的影响在周期性牵张调控血管平滑肌细胞增殖、迁移中的作用及机制研究，国家自然科学基金面上项目，2019.01-2022.12，63万
3. IKCa通道在周期性牵张调控血管平滑肌细胞表型转变、增殖、迁移中的作用及机制研究，国家自然科学基金面上项目，2014.01-2018.12，90万。
4. 切应力对血管平滑肌细胞BKCa通道的影响及Beta1 、Beta3 整合素在其中所起的作用，国家自然科学基金面上项目，2010.01-2012.12，44万。
5. 炎症介质刺激下白细胞表面L-选择素的表达、分布和动力学变化的研究，教育部青年教师基金， 2009.01-2011.12，3.6万。
主要论著
1. Xiaoling Jia, Xinlan Chen, Chao Gao, et al. Functional cooperation between IKCa and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca2+ influx and ERK1/2 activation. Cell Prolif 2022 23;e13385.
2. Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang. Piezo1 channel-mediated Ca2+ signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-αand IL-6 in microglial cells. Glila. 2022. doi: 10.1002/glia.24311.
3. Xiaoling Jia, Qingmao Yang, Chao Gao, et al. Stimulation of vascular smooth muscle cell proliferation by stiff matrix via the IKCa channel‐dependent Ca2+ signaling. J Cell Physiol . 2021;236(10):6897-6906.
4. Xiaoling Jia, Chao Gao, Xia Wang, et al. Differential regulation by mechanical stretch of the expressions of large‑conductance Ca2+‑activated K+ channel and L‑type voltage‑dependent Ca2+ channel in rat uterine smooth muscle cells. J Membr Biol. 2022;255(2-3):357-361.
5. Xiaoling Jia, Hao Su, Xinlan Chen, et al. A critical role of the KCa3.1 channel in mechanical stretch-induced proliferation of rat bone marrow-derived mesenchymal stem cells. J Cell Mol Med. 2020 ;24(6):3739-3744.
6. Yang Yang, Qingmao Yang, Fang Zhou, Yunhui Zhao, Xiaoling Jia*, Xiaoyan Yuan, Yubo Fan. Electrospun PELCL membranes loaded with QK peptide for enhancement of vascular endothelial cell growth. J Mater Sci Mater Med. 2016 ;27(6):106. co-correspondence
7. Fang Zhou, Xiaoling Jia#, Qingmao Yang, et al. Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modifified PEG-trimethyl chitosan. Biomater Sci 2016 May 26;4(5):849-56. co-first
8. Fang Zhou, Xiaoling Jia#, Yang Yang, et al. Nanofiber-mediated microRNA-126 delivery to vascular endothelial cells for blood vessel regeneration. Acta Biomater. 2016 ;43:303-313. co-first
9. Zhou Fang, Xiaoling Jia#, Yang Y, et al. Peptide-modifified PELCL electrospun membranes for regulation of vascular endothelial cells. Mater Sci Eng C Mater Biol Appl. 2016 ;68:623-631. co-first
10. Jie Fan, Xiaoling Jia, Yan Huang, et al. Greater scaffold permeability promotes growth of osteoblastic cells in a perfused bioreactor. J Tissue Eng Regen Med. 2015;9(12):E210-8.
11. Xufeng Niu, Pin Chen, Xiaoling Jia, et al. Microencapsulation of mechano growth factor E peptide for sustained delivery and bioactivity maintenance. Int J Pharm. 2014;469(1):214-21.
12. Hong Zhang, Xiaoling Jia#, Fengxuan Han, et al. Dual-Delivery of VEGF and PDGF by Double-layered Electrospun Membranes for Blood Vessel Regeneration. Biomaterials. 2013;34(9): 2202-2212. co-first
13. Fengxuan Han, Xiaoling Jia#, D Dai, et al. Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF. Biomaterials. 2013;34(30): 7302-7312. co-first
14. Xiaoling Jia, Jingyun Yang, Wei Song, et al. Involvement of large conductance Ca2+-activated K+ channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation. pflugers archiv-european journal of physiology 2013;465:221-232.
15. Meiliang Li, Xiaoling Jia#, Jingyun Yang , et al. Effect of tannic acid on properties of soybean seed ferritin: A model for interaction between naturally -occurring components in foodstuffs. Food Chemistry 2012;133:410-415 co-first
16. Xiaoling Jia, Chenguang Zhao, Ping Li, et al. Sustained release of VEGF by coaxial electrospun dextran/PLGA fibrous membranes in vascular tissue engineering. Journal of biomaterial science-polymer edition. 2011;22:1811-1827.
17. Chenyan Lv, Xiaoling Jia#, Meiliang Li, et al. Optimization of extraction process of crude protein from grape seeds by RSM. Food Sci and Technol Res 2011;17:437-445. Co-first co-first
18. Yan Huang, Xiaoling Jia, Ke Bai, et al. Effects of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells. Arch Med Res 2010 ;41(7):497-505.
19. Ping Li, Feng X, xiaoling Jia, Yubo Fan. nfluences of tensile load on in vitro degradation of an electrospun poly(L-lactide-co-glycolide) scaffold. Acta Biomater. 2010;6(8):2991-2996.
20. Xin Gu, Xiaoling Jia#, Jiannan Feng, et al. Molecular modeling and affinity determination of scFv antibody: proper linker peptide enhances its activity. Ann Biomed Eng. 2010, 38:537-549. co-first
21. Xiaoling Jia, Juan Chen and Mian Long. IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1. Chinese Science Bulletin. 2009,54:2787-2793.
22. Mian Long, Xiaoling Jia. Selectin shedding regulates two-dimensional binding to PSGL-1. Biorheology 2008, 45:74-75.
23. Li Wu, Botao Xiao, Xiaoling Jia, et al. Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin glycoprotein ligand-1 interactions. Journal of biological chemistry 2007, 282:9846-9854 |